[HTML][HTML] Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome

C Sorrentino, SL Ciummo, L D'Antonio… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Breast cancer (BC) progression to metastatic disease is the leading cause of
death in women worldwide. Metastasis is driven by cancer stem cells (CSCs) and signals …

Interleukin-30/IL27p28 shapes prostate cancer stem-like cell behavior and is critical for tumor onset and metastasization

C Sorrentino, SL Ciummo, G Cipollone, S Caputo… - Cancer Research, 2018 - AACR
Prostate cancer stem-like cells (PCSLC) are believed to be responsible for prostate cancer
onset and metastasis. Autocrine and microenvironmental signals dictate PCSLC behavior …

[HTML][HTML] Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival

L D'Antonio, C Fieni, SL Ciummo, S Vespa… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Progression of colorectal cancer (CRC), a leading cause of cancer-related
death worldwide, is driven by colorectal cancer stem cells (CR-CSCs), which are regulated …

[HTML][HTML] The CXC motif chemokine ligand 1 sustains breast cancer stem cell self-renewal and promotes tumor progression and immune escape programs

SL Ciummo, L D'Antonio, C Sorrentino… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by
cancer stem cells (CSC). The chemokine CXC motif ligand-1 (CXCL1) is involved in BC …

[HTML][HTML] CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality

C Sorrentino, L D'Antonio, SL Ciummo, C Fieni… - Journal of Hematology & …, 2022 - Springer
Background Metastatic prostate cancer (PC) is a leading cause of cancer death in men
worldwide. Targeting of the culprits of disease progression is an unmet need. Interleukin (IL) …

Disclosure of climate change risk in credit ratings

S Ciummo, F Walch, M Breitenstein - ECB Occasional Paper, 2022 - papers.ssrn.com
Climate change can be a source of financial risk. This paper examines how credit rating
agencies accepted by the Eurosystem incorporate climate change risk in their credit ratings …

[BOOK][B] Disclosure of climate change risk in credit ratings: An analytical framework to perform a status-quo assessment of the disclosure of climate change risks in …

M Breitenstein, S Ciummo, F Walch - 2022 - econstor.eu
Climate change can be a source of financial risk. This paper examines how credit rating
agencies accepted by the Eurosystem incorporate climate change risk in their credit ratings …

[HTML][HTML] Targeting Interleukin (IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves …

C Sorrentino, Z Yin, S Ciummo, P Lanuti, LF Lu… - … for ImmunoTherapy of …, 2019 - Springer
Abstract Background Interleukin (IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-
Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and …

[HTML][HTML] Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling

C Sorrentino, SL Ciummo, L D'Antonio… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Dear Editor, We recently identified interleukin (IL) 30 as a chief regulator of prostate and
breast cancer (BC) microenvironments. 1, 2, 3 Produced by cancer and infiltrating myeloid …

[HTML][HTML] Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways

SL Ciummo, C Sorrentino, C Fieni… - Journal of Experimental & …, 2023 - Springer
Background Cancer-endothelial interplay is crucial for tumor behavior, yet the molecular
mechanisms involved are largely unknown. Interleukin (IL)-30, which is expressed as a …