Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Blood vessels are highly organized and complex structure, which are far more than simple
tubes conducting the blood to almost any tissue of the body. They are able to autonomously …

The proteoglycan decorin is expressed by sprouting but not quiescent endothelial cells, and
angiogenesis is dysregulated in its absence. Previously, we have shown that decorin core …

Endorepellin, the C-terminal module of perlecan, has angiostatic activity. Here we provide
definitive genetic and biochemical evidence that the functional endorepellin receptor is the …

Apoptosis of primary fibroblasts was observed in vivo during wound healing in skin and is
expected to occur in other organs as well; however, the environmental signal for induction of …

Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many
essential processes, including embryogenesis, wound healing and tissue organization, with …

Cellular receptors for collagens belong to the family of β 1 integrins. In the epidermis,
integrin α 2 β 1 is the only collagen-binding integrin present. Its expression is restricted to …