[HTML][HTML] PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages
K Kauffman, D Manfra, D Nowakowska, M Zafari… - Cancer Research …, 2023 - AACR
The immune suppressive microenvironment is a major culprit for difficult-to-treat solid
cancers. Particularly, inhibitory tumor-associated macrophages (TAM) define the resistant …
cancers. Particularly, inhibitory tumor-associated macrophages (TAM) define the resistant …
862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses …
P Nguyen, R Phennicie, K Kauffman, D Nowakowska… - 2020 - jitc.bmj.com
Background Macrophages play an important role in cancer by modulating both the innate
and adaptive parts of the immune system. In non-pathological conditions, multiple subsets of …
and adaptive parts of the immune system. In non-pathological conditions, multiple subsets of …
886 targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays …
S Sazinsky, P Nguyen, M Zafari, R Phennicie, J Wahle… - 2021 - jitc.bmj.com
Background VSIG4 (V-set immunoglobulin-domain-containing 4) is a B7 family related
protein with known roles as a complement receptor involved in pathogen clearance as well …
protein with known roles as a complement receptor involved in pathogen clearance as well …
Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor …
A Nguyen, J Ritter, M Zafari, D Manfra… - Molecular Cancer …, 2021 - AACR
Suppressive myeloid populations in the tumor microenvironment are associated with worse
survival of cancer patients and low effectiveness of T cell checkpoint inhibitors. Recently …
survival of cancer patients and low effectiveness of T cell checkpoint inhibitors. Recently …
Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in …
S Sazinsky, A Nguyen, M Zafari, R Phennicie… - Molecular Cancer …, 2021 - AACR
Abstract VSIG4 (V-set immunoglobulin-domain-containing 4) is a B7 family related protein
with known roles as a complement receptor involved in pathogen clearance, via interactions …
with known roles as a complement receptor involved in pathogen clearance, via interactions …
VTX-0811, a first-in-class PSGL-1 blocking monoclonal antibody, repolarizes tumor associated macrophages and induces inflammation in the tumor microenvironment …
I Feldman, T Novobrantseva, A Nguyen, J Ritter… - Cancer Research, 2022 - AACR
Suppressive myeloid cells in the tumor microenvironment (TME) are associated with poor
survival of cancer patients and resistance to T cell checkpoint inhibitors. These myeloid cells …
survival of cancer patients and resistance to T cell checkpoint inhibitors. These myeloid cells …
Discovery of a novel TIM3 binding partner and a key role for TIM3 on macrophages: Identification of specific antibodies capable of converting immune-suppressive …
J Wong, R Phennicie, I Feldman, S Sathyanarayanan… - Cancer Research, 2016 - AACR
Abstract Our Translational Science Platform uses an unbiased bioinformatics-based
approach to interrogate particular cell types within the tumor microenvironment (TME). Given …
approach to interrogate particular cell types within the tumor microenvironment (TME). Given …
PSGL-1 is a novel macrophage checkpoint in immuno-oncology.
D Nowakowska, R Phennicie, K Kauffman, M Zafari… - 2020 - ascopubs.org
e15090 Background: Macrophages are both antigen presenting and effector cells of the
innate immune system and play an important role in tissue homeostasis as well as in …
innate immune system and play an important role in tissue homeostasis as well as in …
[CITATION][C] PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor …
P Nguyen, J Ritter, M Zafari… - JOURNAL …, 2021 - BMJ PUBLISHING GROUP BRITISH …