Background Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and is
effective in chronic lymphocytic leukemia (CLL). Resistance to irreversible kinase inhibitors …

Background Myeloid cells are an abundant leukocyte in many types of tumors and contribute
to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of …

Ibrutinib, a Bruton's tyrosine kinase inhibitor, is active in CLL, but resistance may emerge.
The authors observed the emergence of a CLL clone with a cysteine-to-serine change in …

This review focuses on the control of nuclear import and export pathways by the small
GTPase Ran. Transport of signal-containing cargo substrates is mediated by receptors that …

Abstract Ibrutinib (PCI-32765) is a highly potent oral Bruton tyrosine kinase (BTK) inhibitor in
clinical development for treating B-cell lymphoproliferative diseases. Patients with chronic …

Positive regulation of gene expression by the yeast Saccharomyces cerevisiae transcription
factor Yap1p is required for normal tolerance of oxidative stress elicited by the redox-active …

Dysregulated metabolism is a hallmark of cancer that manifests through alterations in
bioenergetic and biosynthetic pathways to enable tumor cell proliferation and survival …

The Saccharomyces cerevisiae AP-1 protein (yAP-1) is a key mediator of oxidative stress
tolerance. Transcriptional activation by yAP-1 has been shown to be inducible by exposure …

Nuclear transport factor 2 (NTF2) is a soluble transport protein originally identified by its
ability to stimulate nuclear localization signal (NLS)-dependent protein import in digitonin …

Ran is a Ras-related GTPase that is essential for the transport of protein and RNA between
the nucleus and the cytoplasm. Proteins that regulate the GTPase cycle and subcellular …