This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical
oncology to treat solid tumors with irreversible electroporation (IRE) and …

γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen
presentation, which makes them a highly promising effector cell compartment for cancer …

Advances in the treatment of metastatic melanoma have improved responses and survival.
However, many patients continue to experience resistance or toxicity to treatment …

Noncoding regulatory microRNAs (miRNAs) of cellular and viral origin control gene
expression by repressing the translation of mRNAs into protein. Interestingly, miRNAs are …

Background The granulocyte-macrophage colony-stimulating factor-transduced allogeneic
prostate cancer cells vaccine (GVAX) has antitumour activity against prostate cancer; …

Purpose: The CROSS trial established neoadjuvant chemoradiotherapy (nCRT) for patients
with resectable esophageal adenocarcinoma (rEAC). In the PERFECT trial, we investigated …

Abstract Programmed death-ligand 1 (PD-L1) is expressed in various immune cells and
tumor cells, and is able to bind to PD-1 on T lymphocytes, thereby inhibiting their function. At …

The field of tumor vaccination is currently undergoing a shift in focus, from individualized
tailor-made vaccines to more generally applicable vaccine formulations. Although primarily …

Background Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment
option for patients with oligometastatic disease. SABR delivers precise, high-dose …

Production of immunosuppressive factors is one of the mechanisms by which tumors evade
immunosurveillance. Soluble factors hampering dendritic cell (DC) development have …