The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

S Leung, X Liu, L Fang, X Chen, T Guo… - Cellular & molecular …, 2010 - nature.com
The propagation and regulation of an immune response is driven by a network of effector
and regulatory T (Treg) cells. The interplay of effector T and Treg cells determines the …

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

H Nie, Y Zheng, R Li, TB Guo, D He, L Fang, X Liu… - Nature medicine, 2013 - nature.com
Regulatory T (Treg) cells suppress autoimmune disease, and impaired Treg cell function is
associated with rheumatoid arthritis. Here we demonstrate that forkhead box P3 (FOXP3) …

Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B

G Yang, A Liu, Q Xie, TB Guo, B Wan… - International …, 2007 - academic.oup.com
Chronic activity of hepatitis B is thought to involve aberrant immune tolerance of unknown
mechanism. In this study, we examined the role of CD4+ CD25+ Foxp3+ regulatory T cells in …

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

X Liu, S Leung, C Wang, Z Tan, J Wang, TB Guo… - Nature medicine, 2010 - nature.com
Abstract Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple
sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T …

Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer

L Hao, C Zhang, Y Qiu, L Wang, Y Luo, M Jin, Y Zhang… - Cancer letters, 2007 - Elsevier
We investigated the expression of CXC chemokine receptor 4 (CXCR4), vascular
endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 to elucidate …

Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1β through the NF‐κB and MAPK pathways in …

W Zheng, R Li, H Pan, D He, R Xu… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Osteopontin (OPN) is a proinflammatory protein with a critical role in leukocyte
migration. Although OPN has been implicated in rheumatoid arthritis (RA), its underlying …

Drug targets in the cytokine universe for autoimmune disease

X Liu, L Fang, TB Guo, H Mei, JZ Zhang - Trends in immunology, 2013 - cell.com
In autoimmune disease, a network of diverse cytokines is produced in association with
disease susceptibility to constitute the 'cytokine milieu'that drives chronic inflammation. It …

Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis

Z Wang, J Qiu, TB Guo, A Liu, Y Wang, Y Li… - The Journal of …, 2007 - journals.aai.org
Abstract Ethyl 2-[4-(12-β-artemisininoxy)] phenoxylpropionate (SM933) is a novel derivative
of artemisinin, an herbal compound approved for the treatment of malaria. In this study, we …

Angiogenesis by transplantation of HIF‐1α modified EPCs into ischemic limbs

M Jiang, B Wang, C Wang, B He, H Fan… - Journal of cellular …, 2008 - Wiley Online Library
Hypoxia inducible factor‐1α (HIF‐1α) is a key determinant of oxygen‐dependent gene
regulation in angiogenesis. HIF‐1α overexpression may be beneficial in cell therapy of …

Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-γ in experimental autoimmune encephalomyelitis

Y Ren, L Lu, TB Guo, J Qiu, Y Yang, A Liu… - The Journal of …, 2008 - journals.aai.org
Berbamine (BM) is an herbal compound derived from Berberis vulgaris L commonly used in
traditional Chinese medicine. In this study, we show that BM has potent anti-inflammatory …