Epithelial tumors of the lacrimal gland: prognostic and therapeutic significance of histologic types

LE Zimmerman, TE Sanders… - International …, 1962 - journals.lww.com
Lorenz E. Zimmerman, Theodore E. Sanders, and Lauren V. Ackerman wrr A veRY FEw
noteworthy exceptions, the ophthalmic literature pertaining to epithelial tumors of the …

Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease

TJ Sanders, NE McCarthy, EM Giles, KLM Davidson… - Gastroenterology, 2014 - Elsevier
Background & Aims Reduced generation of all-trans retinoic acid (RA) by CD103+ intestinal
dendritic cells (DCs) is linked to intestinal inflammation in mice. However, the role of RA in …

A role for gut-associated lymphoid tissue in shaping the human B cell repertoire

A Vossenkämper, PA Blair, N Safinia… - Journal of Experimental …, 2013 - rupress.org
We have tracked the fate of immature human B cells at a critical stage in their development
when the mature B cell repertoire is shaped. We show that a major subset of bone marrow …

[HTML][HTML] Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn's disease

NE McCarthy, CR Hedin, TJ Sanders… - The Journal of …, 2015 - Am Soc Clin Investig
Tumor-derived and bacterial phosphoantigens are recognized by unconventional
lymphocytes that express a Vγ9Vδ2 T cell receptor (Vδ2 T cells) and mediate host protection …

Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells

NE McCarthy, Z Bashir, A Vossenkämper… - The Journal of …, 2013 - journals.aai.org
In nonhuman primates, Vγ9Vδ2+(Vδ2) T cells proliferate and accumulate in mucosal tissues
following microbial activation. Human Vδ2T cells produce proinflammatory cytokines in …

Use of methylation patterns to determine expansion of stem cell clones in human colon tissue

TA Graham, A Humphries, T Sanders… - Gastroenterology, 2011 - Elsevier
Background & Aims It is a challenge to determine the dynamics of stem cells within human
epithelial tissues such as colonic crypts. By tracking methylation patterns of nonexpressed …

A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease

A Vossenkämper, C Hundsrucker, K Page… - Gastroenterology, 2014 - Elsevier
Background & Aims T cells mediate the development of inflammation in inflammatory bowel
disease (IBD). We investigated the effects of an antibody against CD3 called otelixizumab …

[HTML][HTML] Hydrogen sulfide reduces myeloid-derived suppressor cell-mediated inflammatory response in a model of Helicobacter hepaticus-induced colitis

P De Cicco, T Sanders, G Cirino, KJ Maloy… - Frontiers in …, 2018 - frontiersin.org
Chronic inflammation contributes to tumor initiation in colitis-associated colorectal cancer
(CRC). Indeed, inflammatory bowel disease (IBD) patients show an increased risk of …

[HTML][HTML] Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease

EM Giles, TJ Sanders, NE McCarthy, J Lung… - Mucosal …, 2017 - nature.com
Abstract Type 1 interferon (IFN-1) promotes regulatory T-cell function to suppress
inflammation in the mouse intestine, but little is known about IFN-1 in the human gut. We …

[HTML][HTML] Domain binding and isotype dictate the activity of anti-human OX40 antibodies

J Griffiths, K Hussain, HL Smith, T Sanders… - … for ImmunoTherapy of …, 2020 - ncbi.nlm.nih.gov
Background Previous data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice
through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells …