Performance of next-generation sequencing for the detection of microsatellite instability in colorectal cancer with deficient DNA mismatch repair
Background & Aims Next-generation sequencing (NGS) was recently approved by the
United States Food and Drug Administration to detect microsatellite instability (MSI) arising …
United States Food and Drug Administration to detect microsatellite instability (MSI) arising …
[HTML][HTML] RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status
C Dorard, C Madry, O Buhard, S Toifl, S Didusch… - Oncogene, 2023 - nature.com
More than 30% of all human cancers are driven by RAS mutations and activating KRAS
mutations are present in 40% of colorectal cancer (CRC) in the two main CRC subgroups …
mutations are present in 40% of colorectal cancer (CRC) in the two main CRC subgroups …
[HTML][HTML] Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer
R Cohen, V Jonchère… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) are sensitive
to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain …
to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain …
[HTML][HTML] Identification of positively and negatively selected driver gene mutations associated with colorectal cancer with microsatellite instability
V Jonchère, L Marisa, M Greene, A Virouleau… - Cellular and molecular …, 2018 - Elsevier
Background & Aims Recent studies have shown that cancers arise as a result of the positive
selection of driver somatic events in tumor DNA, with negative selection playing only a minor …
selection of driver somatic events in tumor DNA, with negative selection playing only a minor …
[PDF][PDF] Phenotypes prediction from gene expression data with deep multilayer perceptron and unsupervised pre-training
B Hanczar, M Henriette, T Ratovomanana… - Int J Biosci Biochem …, 2018 - ijbbb.org
Machine learning is widely used for phenotype prediction from gene expression data.
However, deep learning, that is currently one of the most performant methods, have been …
However, deep learning, that is currently one of the most performant methods, have been …
Prediction of Response to Immune Checkpoint Blockade in Patients with Metastatic Colorectal Cancer with Microsatellite Instability
Tumors with microsatellite instability (MSI) represent a paradigm for the success of immune
checkpoint inhibitor (ICI)-based immunotherapy, particularly in patients with metastatic …
checkpoint inhibitor (ICI)-based immunotherapy, particularly in patients with metastatic …
[PDF][PDF] Nuclear HSP110 chaperone expression is associated with cancer progression, a poor response to chemotherapy and poor prognosis in colorectal cancer …
K Noel, OB A'dem Bokhari, LR Gauthier, R Bertrand… - Sorbonne …, 2022 - theses.fr
Background and aims: Colorectal cancer (CRC) patients whose tumors exhibit microsatellite
instability (MSI) have distinct clinicopathological characteristics consisting of factors …
instability (MSI) have distinct clinicopathological characteristics consisting of factors …
Method to diagnose MSI cancer
The present invention relates to the field of the diagnostic of MSI cancer. In the present work,
the inventors evaluated the performance of MSISensor for the detection of MSI in dMMR/MSI …
the inventors evaluated the performance of MSISensor for the detection of MSI in dMMR/MSI …
Instabilité des microsatellites et cancer: mise à profit du séquençage de nouvelle génération pour l'identification de ce phénotype tumoral et l'analyse des mécanismes …
T Ratovomanana - 2021 - theses.hal.science
L'instabilité des séquences microsatellites de l'ADN (MSI) signe un phénotype tumoral
fréquent associé à de nombreux cancers chez l'homme. Elle est consécutive à la déficience …
fréquent associé à de nombreux cancers chez l'homme. Elle est consécutive à la déficience …