Background An immune active cancer phenotype typified by a T helper 1 (Th-1) immune
response has been associated with increased responsiveness to immunotherapy and …

More than one million prostate biopsies are performed in the United States every year. A
failure to find cancer is not definitive in a significant percentage of patients due to the …

Epigenetic transcriptional regulation plays an important role in the life cycle of human
papillomaviruses (HPVs) and the carcinogenic progression of anogenital HPV associated …

The development of immune checkpoint blockade (ICB) therapies has been instrumental in
advancing the field of immunotherapy. Despite the prominence of these treatments, many …

Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic
and long lasting but occur in a subset of tumors and are largely dependent upon the pre …

Mutations in the Drosophila variable nurse cells (vnc) gene result in female sterility and
oogenesis defects, including egg chambers with too many or too few nurse cells. We show …

Immune oncology (IO) is challenged to expand its usefulness to a broader range of cancers.
A second generation of IO agents acting beyond the realm of Checkpoint Inhibitor Therapy …

The L1 gene of human papillomavirus-18 (HPV-18) is consistently hypermethylated in
cervical carcinomas, but frequently hypo-or unmethylated in exfoliated cells from …

Streptococcus pneumoniae causes respiratory and other invasive infections. Increased
resistance of this bacterium to antibiotics necessitates new approaches to the treatment of …

Background The balance between immune-stimulatory and immune-suppressive
mechanisms in the tumour microenvironment is associated with tumour rejection and can …