The mammalian PCP pathway regulates diverse developmental processes requiring
coordinated cellular movement, including neural tube closure and cochlear stereociliary …

Artemisin combination therapy (ACT) is the main treatment option for malaria, which is
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …

Osmiophilic bodies are membrane‐bound vesicles, found predominantly in Plasmodium
female gametocytes, that become progressively more abundant as the gametocyte reaches …

Background Melanoma brain metastases (MBMs) are a challenging clinical problem with
high morbidity and mortality. Although first-line dabrafenib–trametinib and ipilimumab …

We present SVclone, a computational method for inferring the cancer cell fraction of
structural variant (SV) breakpoints from whole-genome sequencing data. SVclone …

The development of new antimalarials is required because of the threat of resistance to
current antimalarial therapies. To discover new antimalarial chemotypes, we screened the …

Metazoans inherited genes from unicellular ancestors that perform essential biological
processes such as cell division, metabolism and protein translation. Functioning …

In the published version of this paper, the members of the Pan-Cancer Analysis of Whole
Genomes (PCAWG) Consortium were listed in the Supplementary Information; however …

Advanced breast cancers show varying degrees of metastasis; however, reliable biomarkers
of metastatic disease progression remain unknown. In circulation, immune cells are the first …

Introduction/Background Poly-ADP ribose polymerase inhibitors (PARPi) provide impressive
therapeutic responses in carcinomas with deficiencies in the homologous recombination …