Because the benefits of immune checkpoint blockade may be restricted to tumors with pre-
existing immune recognition, novel therapies that facilitate de novo immune activation are …

Abstract TATA binding protein (TBP)[1, 2] is a key regulator of RNA polymerase transcription.
It binds to core promoters, often in large multiprotein complexes, and nucleates RNA …

It is generally believed that most tumor antigens are passively released from either health or
dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock …

A missense mutation within the histone acetyltransferase (HAT) domain of the TATA binding
protein-associated factor TAF1 induces ts13 cells to undergo a late G 1 arrest and …

Background Autophagy regulates innate and adaptive immune responses to pathogens and
tumors. We have reported that autophagosomes derived from tumor cells after proteasome …

Cyclin D1 is an oncogene that regulates progression through the G 1 phase of the cell cycle.
A temperature-sensitive missense mutation in the transcription factor TAF1/TAF II 250 …

The homeodomain transcription factor Pitx2 and the T-box transcription factors are essential
for organogenesis. Pitx2 and T-box genes are induced by growth factors and function as …

Histone deacetylase inhibitors (HDIs) induce cell cycle arrest, differentiation, or apoptosis in
numerous cancer cell types both in vivo and in vitro. These dramatic effects are the result of …

Background Tumor-derived autophagosome vaccines (DRibbles) have the potential to
broaden immune response to poorly immunogenic tumors. Methods Autologous vaccine …

Background SARS-CoV-2 (CoV2) has precipitated a global pandemic and the effectiveness
of standard vaccine strategies to induce potent and persistent immunity to CoV2 is in …