Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

Hyperthermia (HT) is a potent sensitiser for radiotherapy (RT) and chemotherapy (CT) and
has been proven to modulate directly or indirectly cells of the innate and adaptive immune …

Gut microbial dysbiosis is associated with the development of autoimmune disease, but the
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …

The immunogenicity of malignant cells has recently been acknowledged as a critical
determinant of efficacy in cancer therapy. Thus, besides developing direct …

Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease.
Impaired clearance functions for dying cells may explain accumulation of nuclear …

Impaired clearance of apoptotic cell material has been implicated in the pathogenesis of
systemic lupus erythematosus (SLE). Besides many other molecules, C1q and DNaseI …

Phosphatidylserine (PS), a phospholipid predominantly found in the inner leaflet of
eukaryotic cellular membranes, plays important roles in many biological processes. During …

The NALP3 inflammasome is activated by low intracellular potassium concentrations [K+] i,
leading to the secretion of the proinflammatory cytokine IL-1β. However, the mechanism of …

Strategies to enhance the immunogenicity of tumors are urgently needed. Although
vaccination with irradiated dying lymphoma cells recruits a tumor-specific immune response …