Objectives: These studies describe molecular forms of circulating B-type natriuretic peptide
(BNP) as well as their biological activity. Background: Increased circulating levels of …

Background—The myocardium secretes B-type natriuretic peptide (BNP) in response to
stimuli associated with heart failure (HF). However, high immunoreactive-BNP levels in …

Human pro-B-type natriuretic peptide (proBNP), the precursor for B-type natriuretic peptide
(BNP), was expressed in Chinese hamster ovary cells (CHO) and compared by Western blot …

Background—Multiple B-type natriuretic peptide (BNP) fragments circulate in patients with
heart failure (HF) but the types and relative quantities, particularly in relation to bioactive …

The coleopteran insect western corn rootworm (WCR)(Diabrotica virgifera virgifera LeConte)
is a devastating crop pest in North America and Europe. Although crop plants that produce …

Background—A method for identifying tissue experiencing hypoxic stress due to
atherosclerotic vascular disease would be clinically useful. Vascular endothelial growth …

ABSTRACT T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing
activity in humans, but cytokine release-related toxicities have affected their clinical utility …

The coleopteran insect western corn rootworm (WCR, Diabrotica virgifera virgifera) is an
economically important pest in North America and Europe. Transgenic corn plants …

Background Therapeutic options currently available for metastatic castration-resistant
prostate cancer (mCRPC) do not extend median overall survival> 6 months. Therefore, the …

The use of recombinant interleukin-2 (IL-2) as a therapeutic protein has been limited by
significant toxicities despite its demonstrated ability to induce durable tumor-regression in …