User profiles for "author:Uzma Rentia"
 | Uzma RentiaGeorge Washington University Verified email at gwu.edu Cited by 59 |
HAPHPIPE: haplotype reconstruction and Phylodynamics for deep sequencing of Intrahost viral populations
ML Bendall, KM Gibson, MC Steiner… - Molecular biology …, 2021 - academic.oup.com
Deep sequencing of viral populations using next-generation sequencing (NGS) offers
opportunities to understand and investigate evolution, transmission dynamics, and …
opportunities to understand and investigate evolution, transmission dynamics, and …
[HTML][HTML] Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Background Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest
cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors …
cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors …
Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
JI McDonald, N Diab, E Arthofer, M Hadley, T Kanholm… - Cancer research, 2021 - AACR
Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity,
resistance to standard-of-care therapies, and poor response to alternative treatments such …
resistance to standard-of-care therapies, and poor response to alternative treatments such …
[HTML][HTML] Locus specific endogenous retroviral expression associated with Alzheimer's disease
Methods We combined two, publicly available RNA-Seq datasets with a third, novel dataset
for a total cohort of 103 patients with Alzheimer's disease and 45 healthy controls. We use …
for a total cohort of 103 patients with Alzheimer's disease and 45 healthy controls. We use …
Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Transposable elements (TE) are typically silenced by DNA methylation and repressive
histone modifications in differentiated healthy human tissues. However, TE expression …
histone modifications in differentiated healthy human tissues. However, TE expression …
[HTML][HTML] Validation of variant assembly using HAPHPIPE with Next-Generation sequence data from viruses
Next-generation sequencing (NGS) offers a powerful opportunity to identify low-abundance,
intra-host viral sequence variants, yet the focus of many bioinformatic tools on consensus …
intra-host viral sequence variants, yet the focus of many bioinformatic tools on consensus …
[PDF][PDF] The role of repetitive elements in ovarian cancer initiation and progression
U Rentia, T Kanholm, K Chiappinelli - 2021 - hsrc.himmelfarb.gwu.edu
Background: Ovarian cancer is currently the most lethal gynecologic malignancy. Despite
the poor prognosis, most ovarian cancers are detected at Stages III and IV due to the lack of …
the poor prognosis, most ovarian cancers are detected at Stages III and IV due to the lack of …
Inhibition of DNMTs and RNA editing increases immunogenic transposable element RNA to reduce tumor burden and prolong survival in a murine ovarian cancer …
Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in
women. Preclinical data shows great promise for the treatment of OC with epigenetic …
women. Preclinical data shows great promise for the treatment of OC with epigenetic …
Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis
Abstract Transposable elements (TEs), including LINEs, SINEs, and LTRs, are typically
silenced by epigenetic mechanisms in differentiated healthy tissues. However, TE …
silenced by epigenetic mechanisms in differentiated healthy tissues. However, TE …
Loss of Adar1 increases T cell migration and prolongs survival in ovarian cancer
Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in
women. OC is generally characterized by an immunosuppressive tumor microenvironment …
women. OC is generally characterized by an immunosuppressive tumor microenvironment …