[PDF][PDF] Isotype switching converts anti-CD40 antagonism to agonism to elicit potent antitumor activity
Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display
promising therapeutic activities in cancer and autoimmunity, respectively. We previously …
promising therapeutic activities in cancer and autoimmunity, respectively. We previously …
[HTML][HTML] Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments
J Moreno-Vicente, JE Willoughby… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Despite extensive clinical use, the mechanisms that lead to therapeutic
resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain …
resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain …
BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression
TEC Cummin, KL Cox, TD Murray, AH Turaj… - Blood …, 2020 - ashpublications.org
Although the MYC oncogenic network represents an attractive therapeutic target for
lymphoma, MYC inhibitors have been difficult to develop. Alternatively, inhibitors of …
lymphoma, MYC inhibitors have been difficult to develop. Alternatively, inhibitors of …
[PDF][PDF] Cyclophosphamide depletes tumor infiltrating T regulatory cells and combined with anti-PD-1 therapy improves survival in murine neuroblastoma
ER Webb, J Moreno-Vicente, A Easton, S Lanati… - Iscience, 2022 - cell.com
The outcome for children with high-risk neuroblastoma is poor despite intensive multi-modal
treatment protocols. Toxicity from current treatments is significant, and novel approaches are …
treatment protocols. Toxicity from current treatments is significant, and novel approaches are …
[HTML][HTML] Domain binding and isotype dictate the activity of anti-human OX40 antibodies
J Griffiths, K Hussain, HL Smith, T Sanders… - … for ImmunoTherapy of …, 2020 - ncbi.nlm.nih.gov
Background Previous data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice
through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells …
through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells …