Recent progress in GM-CSF-based cancer immunotherapy

WL Yan, KY Shen, CY Tien, YA Chen, SJ Liu - Immunotherapy, 2017 - Future Medicine
Cancer immunotherapy is a growing field. GM-CSF, a potent cytokine promoting the
differentiation of myeloid cells, can also be used as an immunostimulatory adjuvant to elicit …

NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration

HH Chen, WP Chen, WL Yan, YC Huang… - Journal of cell …, 2015 - journals.biologists.com
Nuclear receptor interaction protein (NRIP, also known as DCAF6 and IQWD1) is a Ca2+-
dependent calmodulin-binding protein. In this study, we newly identify NRIP as a Z-disc …

[HTML][HTML] Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment

WL Yan, CC Wu, KY Shen, SJ Liu - Journal for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background The major challenge of antitumor immunotherapy is dealing with the
immunosuppressive tumor microenvironment, which involves immature myeloid cell …

Gemcitabine enhances antitumor efficacy of recombinant lipoimmunogen-based immunotherapy

LS Chang, WL Yan, YW Chang, YC Yeh… - …, 2016 - Taylor & Francis
Although immunotherapy is an attractive approach for cancer treatment, increasing evidence
has shown that the combination of immunotherapy with other treatment modalities may …

[HTML][HTML] Liposomal TLR9 agonist combined with TLR2 agonist-fused antigen can modulate tumor microenvironment through dendritic cells

KY Shen, HY Liu, WL Yan, CC Wu, MH Lee, CH Leng… - Cancers, 2020 - mdpi.com
Dendritic cells (DCs) are antigen-presenting cells involved in T cell activation and
differentiation to regulate immune responses. Lipoimmunogens can be developed as …

Gemcitabine synergistically enhances anti-tumor effects of recombinant immunogen-based cancer immunotherapy

SJ Liu, LS Chang, WL Yan, YC Yeh… - Annals of …, 2015 - annalsofoncology.org
Background: Although cytotoxic T lymphocytes (CTLs) play a major role in cancer
immunotherapy, the cancer-derived immunosuppressive cells often limits the success of …

探討 NRIP 在骨骼肌功能上的角色

WL Yan - 國立臺灣大學微生物學研究所學位論文, 2012 - airitilibrary.com
NRIP, nuclear receptor interacting protein, is a novel gene that we identified previously.
NRIP is a ligand-dependent coactivator of androgen receptor and glucocorticoid receptor …