User profiles for "author:Wei Xie"

Wei Xie

- Verified email at tsinghua.edu.cn - Cited by 21575

Wei Xie

- Verified email at vanderbilt.edu - Cited by 2572

Wei Xie

- Verified email at umn.edu - Cited by 2426

Opportunities and obstacles for deep learning in biology and medicine

T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

Electrolyte‐gated transistors for organic and printed electronics

SH Kim, K Hong, W Xie, KH Lee, S Zhang… - Advanced …, 2013 - Wiley Online Library
Here we summarize recent progress in the development of electrolyte‐gated transistors
(EGTs) for organic and printed electronics. EGTs employ a high capacitance electrolyte as …

The role of 3D genome organization in development and cell differentiation

H Zheng, W Xie - Nature reviews Molecular cell biology, 2019 - nature.com
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

[HTML][HTML] Integrative analysis of 111 reference human epigenomes

A Kundaje, W Meuleman, J Ernst, M Bilenky, A Yen… - Nature, 2015 - nature.com
The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …

Thermal degradation chemistry of alkyl quaternary ammonium montmorillonite

W Xie, Z Gao, WP Pan, D Hunter, A Singh… - Chemistry of …, 2001 - ACS Publications
The thermal stability of organically modified layered silicate (OLS) plays a key role in the
synthesis and processing of polymer-layered silicate (PLS) nanocomposites. The …

[HTML][HTML] Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

N Maherali, R Sridharan, W Xie, J Utikal, S Eminli… - Cell stem cell, 2007 - cell.com
Ectopic expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to
confer a pluripotent state upon the fibroblast genome, generating induced pluripotent stem …

[HTML][HTML] Chromatin architecture reorganization during stem cell differentiation

JR Dixon, I Jung, S Selvaraj, Y Shen… - Nature, 2015 - nature.com
Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

[PDF][PDF] Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures

MH Chin, MJ Mason, W Xie, S Volinia, M Singer… - Cell stem cell, 2009 - cell.com
Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …

[HTML][HTML] Epigenomic analysis of multilineage differentiation of human embryonic stem cells

W Xie, MD Schultz, R Lister, Z Hou, N Rajagopal… - Cell, 2013 - cell.com
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …

Roles of PLC-β2 and-β3 and PI3Kγ in chemoattractant-mediated signal transduction

Z Li, H Jiang, W Xie, Z Zhang, AV Smrcka, D Wu - Science, 2000 - science.org
The roles of phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC) in
chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kγ …