Opportunities and obstacles for deep learning in biology and medicine
T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …
combining raw inputs into layers of intermediate features. These algorithms have recently …
Electrolyte‐gated transistors for organic and printed electronics
Here we summarize recent progress in the development of electrolyte‐gated transistors
(EGTs) for organic and printed electronics. EGTs employ a high capacitance electrolyte as …
(EGTs) for organic and printed electronics. EGTs employ a high capacitance electrolyte as …
The role of 3D genome organization in development and cell differentiation
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …
packaged inside the nucleus. This complex genome organization includes multiscale …
[HTML][HTML] Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …
association with human disease, but epigenomic studies lack a similar reference. To …
Thermal degradation chemistry of alkyl quaternary ammonium montmorillonite
W Xie, Z Gao, WP Pan, D Hunter, A Singh… - Chemistry of …, 2001 - ACS Publications
The thermal stability of organically modified layered silicate (OLS) plays a key role in the
synthesis and processing of polymer-layered silicate (PLS) nanocomposites. The …
synthesis and processing of polymer-layered silicate (PLS) nanocomposites. The …
[HTML][HTML] Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution
Ectopic expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to
confer a pluripotent state upon the fibroblast genome, generating induced pluripotent stem …
confer a pluripotent state upon the fibroblast genome, generating induced pluripotent stem …
[HTML][HTML] Chromatin architecture reorganization during stem cell differentiation
Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …
Although dynamic chromatin structures have been identified in the genome, the full scope of …
[PDF][PDF] Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …
[HTML][HTML] Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …
development, but their precise functions are only partially understood. To investigate …
Roles of PLC-β2 and-β3 and PI3Kγ in chemoattractant-mediated signal transduction
Z Li, H Jiang, W Xie, Z Zhang, AV Smrcka, D Wu - Science, 2000 - science.org
The roles of phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC) in
chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kγ …
chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kγ …