As alternatives to small-molecular proteolysis-targeting chimeras (PROTAC), peptide-based
molecular glues (MG) are a broad range of dual-functional ligands that simultaneously bind …

Background Although anti-programmed cell death protein 1 (PD-1) immunotherapy is
greatly effective in melanoma treatment, low response rate and treatment resistance …

Abstract Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the
degradation of intracellular proteins in lysosomes, is upregulated in tumors for pro …

Chirality in biomolecules is ubiquitous in our world, but oral nanomedicines constructed from
chiral peptides are extremely rare, principally because of the immature nanofabrication and …

Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–
protein interactions (PPIs), has been hampered by their inefficacious cellular internalization …

In nature, cells rely on a structural framework called the “cytoskeleton” to maintain their
shape and polarity. Based on this, herein a new class of cell‐mimicking nanomedicine using …

In the conserved autophagy pathway, the double-membrane autophagosome (AP) engulfs
cellular components to be delivered for degradation in the lysosome. While only sealed AP …

Targeted and immunological therapy have revolutionized the malignancy treatment, but is
suffering from the dose‐limiting side effects and inadequate responsiveness. The emerging …

Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as
therapeutics in human diseases, but its clinical translation has been greatly hampered by …

Peptide-derived nanocomposites have been exhibiting fascinating biological advantages,
including but not limited to excellent biocompatibility, biological degradation, high …