Diazinon is activated by CYP2C19 in human liver
WA Kappers, RJ Edwards, S Murray… - Toxicology and applied …, 2001 - Elsevier
Phosphorothioate compounds are used throughout the world as agricultural and domestic
pesticides. Here, the activation of the phosphorothioate diazinon to diazoxon in human liver …
pesticides. Here, the activation of the phosphorothioate diazinon to diazoxon in human liver …
[HTML][HTML] Pharmacokinetics, tissue distribution and excretion of 40 kDa PEG and PEGylated rFVIII (N8-GP) in rats
I Bjørnsdottir, O Sternebring, WA Kappers… - European Journal of …, 2016 - Elsevier
The biologic fate of the [3 H] PEG-moiety incorporated into N8-GP was evaluated based on
single iv bolus doses to rats. Furthermore, the 40 kDa [3 H] PEG-moiety was given …
single iv bolus doses to rats. Furthermore, the 40 kDa [3 H] PEG-moiety was given …
[HTML][HTML] BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells
MJ van Helden, SA Zwarthoff, RJ Arends… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Preclinical studies have firmly established the CD47-signal-regulatory protein
(SIRP) α axis as a myeloid immune checkpoint in cancer, and this is corroborated by …
(SIRP) α axis as a myeloid immune checkpoint in cancer, and this is corroborated by …
Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons
WA Kappers, FMM van Och, EM de Groene… - … /Genetic Toxicology and …, 2000 - Elsevier
Three different in vitro mutation assays were used to investigate the involvement of
cytochrome P450 enzymes in the activation of the nitro-polycyclic aromatic hydrocarbons …
cytochrome P450 enzymes in the activation of the nitro-polycyclic aromatic hydrocarbons …
[HTML][HTML] Long-term safety of PEGylated coagulation factor VIII in the immune-deficient Rowett nude rat
CE Rasmussen, J Nowak, JM Larsen, E Moore… - Journal of …, 2017 - hindawi.com
Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the
treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) …
treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) …
Preclinical profile of BYON3521 predicts an effective and safe MET antibody–drug conjugate
PG Groothuis, DCH Jacobs, IAT Hermens… - Molecular Cancer …, 2023 - AACR
MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely
overexpressed in various solid cancer types, is an attractive target for the development of …
overexpressed in various solid cancer types, is an attractive target for the development of …
1160 Phosphonate-antibody-drug conjugates: a novel immunostimulatory class of ADCs driving inside-out activation of Vγ9Vδ2 T cells leading to selective tumor cell …
MJ van Helden, RC Elgersma, DWJ van Kuppeveld… - 2023 - jitc.bmj.com
Background Gamma delta (γδ) T cells are cytotoxic effector cells that can recognize and kill
tumor cells in a major histocompatibility complex (MHC)-independent fashion. Their …
tumor cells in a major histocompatibility complex (MHC)-independent fashion. Their …
[PDF][PDF] Research Article Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat
CE Rasmussen, J Nowak, JM Larsen, E Moore, D Bell… - 2017 - academia.edu
Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the
treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) …
treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) …