Expanding the US Food and Drug Administration–approved indications for immune
checkpoint inhibitors in patients with cancer has resulted in therapeutic success and …

A randomized, clinical trial was conducted to evaluate the spermicidal agent nonoxynol 9 as
prophylaxis for sexually transmitted diseases. Eight hundred eighteen women using birth …

Oral contraceptive users were compared with nonusers with respect to the rate of cervical
infections by Chlamydia trachomatis and Neisseria gonorrhoeae. The comparison was …

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, improving
outcomes in patients with advanced malignancies. The use of ICIs in clinical practice, and …

A randomized, double-blind, placebo-controlled trial was conducted to evaluate the
spermicidal agent nonoxynol-9 as prophylaxis for cervical infections caused by Chlamydia …

A case-control study was done to evaluate the effectiveness of vaginal spermicides as a
prophylaxis against gonorrhea. The subjects included 735 women with gonorrhea and 958 …

A nested case-control study, also known as an ambidirectional study, is a case-control study
within a cohort study. Although distortion by competing risks is well-recognized in follow-up …

According to the Food and Drug Administration's Guidelines for the Format and Content of
the Clinical and Statistical Sections of New Drug Applications (1), approval of a new drug …

The extension of Kalman filtering to the case of unknown variances is known as adaptive
filtering. Duncan and Horn's (1972) representation of the Kalman time-series model is …

Six methods of combining k independent binomial test statistics are compared with respect
to their median significance levels, asymptotic relative efficiencies, and accuracy of null …