Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding …

Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

At the turn of the last century, the emerging field of medical oncology chose a cytotoxic
approach to cancer therapy over an immune-centered approach at a time when evidence in …

Blockade of angiogenesis can retard tumour growth, but may also paradoxically increase
metastasis,. This paradox may be resolved by vessel normalization, which involves …

Voltage-dependent anion channels (VDACs), also known as mitochondrial porins, are small
channel proteins involved in the translocation of metabolites across the mitochondrial outer …

1. Background Arthritis is a leading cause of pain, disfigurement, and disability in the United
States where nearly one-quarter of all adults have received an affirmative diagnosis. 2 …

Natural killer (NK) cells are important mediators of anti-tumor immunity and are active
against several hematologic malignancies, including multiple myeloma (MM). Umbilical cord …

The immune response consists of a finely-tuned program, the activation of which must be
coupled with inhibitory mechanisms whenever initiated. This ensures tight control of …

Purpose: The CC chemokine receptor 4 (CCR4) is expressed on malignant T cells in
cutaneous T-cell lymphoma (CTCL) as well as on regulatory T cells (Treg). When …

In the nineteenth century, William B. Coley induced durable remission of inoperable
metastatic sarcoma by repeatedly injecting live streptococcus bacilli and, subsequently, heat …