Disordered metabolic states, which are characterised by hypoxia and elevated levels of
metabolites, particularly lactate, contribute to the immunosuppression in the tumour …

Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …

Over the last decade, our understanding of helper/effector T cell differentiation has changed
dramatically. The discovery of interleukin (IL-) 17-producing T cells (Th17) and other subsets …

CD4+ T-helper cells that selectively produce interleukin (IL)-17 (TH17), are critical for host
defence and autoimmunity,,,. Although crucial for TH17 cells in viv o,, IL-23 has been …

Background COVID-19 has spread globally. Epidemiological susceptibility to COVID-19 has
been reported in patients with cancer. We aimed to systematically characterise clinical …

Abstract Interleukin 2 (IL-2), a cytokine linked to human autoimmune disease, limits IL-17
production. Here we found that deletion of the gene encoding the transcription factor STAT3 …

Summary Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper
17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its …

T helper (Th) 17 cells have been proposed to represent a new CD4+ T cell lineage that is
important for host defense against fungi and extracellular bacteria, and the development of …

Summary Interferon-γ (IFN-γ)-mediated adaptive resistance is one major barrier to improving
immunotherapy in solid tumors. However, the mechanisms are not completely understood …

Thirteen novel (E)-α-(methoxyimino) benzeneacetate derivatives, the analogues of
strobilurins, which contain two pharmacophoric substructures of the methyl (E) …