Background Accumulating evidence proposed Janus-associated kinase (JAK) inhibitors as
therapeutic targets warranting rapid investigation. Objective This study evaluated the …

Highlights•Tumor necrosis factor α (TNF-α)-positive leukemia stem cells and leukemia cells
correlate with adverse clinical parameters.•Two forms of TNF-α play different roles in …

COVID-19 is a disease with heterogeneous clinical appearances. Most patients are
asymptomatic or exhibit mild to moderate symptoms; approximately 15% progress to severe …

Dinitrogen (N2) activation and functionalization is of fundamental interest and practical
importance. This review focuses on N2 activation and addition to unsaturated substrates …

Anti-aromatic compounds, as well as small cyclic alkynes or carbynes, are particularly
challenging synthetic goals. The combination of their destabilizing features hinders attempts …

Antigen-escape relapse has emerged as a major challenge for long-term disease control
after CD19-directed therapies, to which dual-targeting of CD19 and CD22 has been …

Topological phases of matter connect mathematical principles to real materials, and may
shape future electronic and quantum technologies. So far, this discipline has mostly focused …

Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in
the plasma membrane, and cells swell, rupture, and then release their contents, including …

B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapies
have shown efficacy in relapsed/refractory multiple myeloma (RRMM). Because the non …

Background T cell immunoglobulin mucin-3 (Tim-3) has been identified as a negative
regulator of anti-tumor immunity. Recent studies highlight the important role of Tim-3 in the …