Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

N Khan, M Jeffers, S Kumar, C Hackett… - Biochemical …, 2008 - portlandpress.com
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a
key role in the control of gene expression through regulation of transcription. While HDACs …

Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase …

A Omuro, AA Brandes, AF Carpentier, A Idbaih… - Neuro …, 2023 - academic.oup.com
Background Addition of temozolomide (TMZ) to radiotherapy (RT) improves overall survival
(OS) in patients with glioblastoma (GBM), but previous studies suggest that patients with …

[PDF][PDF] Effects of PS1 deficiency on membrane protein trafficking in neurons

S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita… - Neuron, 1998 - cell.com
We have examined the trafficking and metabolism of the β-amyloid precursor protein (APP),
an APP homolog (APLP1), and TrkB in neurons that lack PS1. We report that PS1-deficient …

[PDF][PDF] Identification and characterization of novel substrates of Trk receptors in developing neurons

X Qian, A Riccio, Y Zhang, DD Ginty - Neuron, 1998 - cell.com
Neurotrophins influence growth and survival of specific populations of neurons through
activation of Trks, members of the receptor tyrosine kinase (RTK) family. In this report, we …

TMB and inflammatory gene expression associated with clinical outcomes following immunotherapy in advanced melanoma

FS Hodi, JD Wolchok, D Schadendorf, J Larkin… - Cancer Immunology …, 2021 - AACR
Outcomes for patients with melanoma have improved over the past decade as a result of the
development and FDA approval of immunotherapies targeting cytotoxic T lymphocyte …

[HTML][HTML] Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition

AS Laino, D Woods, M Vassallo, X Qian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Inflammatory mediators, including acute phase reactants and cytokines, have
been reported to be associated with clinical efficacy in patients with melanoma and other …

Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies

X Qian, WJ LaRochelle, G Ara, F Wu… - Molecular cancer …, 2006 - AACR
Histone deacetylase inhibitors represent a promising new class of anticancer agents. In the
current investigation, we examined the activity of PXD101, a potent histone deacetylase …

Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease

J Milara, J Lluch, P Almudever, J Freire… - Journal of Allergy and …, 2014 - Elsevier
Background Glucocorticoid functions are markedly impaired in patients with chronic
obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor roflumilast N …

[HTML][HTML] The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo

MT Buckley, J Yoon, H Yee, L Chiriboga… - Journal of Translational …, 2007 - Springer
Background Treatment options for patients with recurrent superficial bladder cancer are
limited, necessitating aggressive exploration of new treatment strategies that effectively …

Activity of the histone deacetylase inhibitor belinostat (PXD101) in preclinical models of prostate cancer

X Qian, G Ara, E Mills, WJ LaRochelle… - … journal of cancer, 2008 - Wiley Online Library
Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer
agents. In the current investigation, we examined the activity of the HDACi belinostat in …