Recent advances of chitosan-based nanoparticles for biomedical and biotechnological applications
Y Gao, Y Wu - International Journal of Biological Macromolecules, 2022 - Elsevier
Chitosan is a natural alkaline polysaccharide, which widely exists in marine crustaceans
such as shrimp and crab, has been shown to have various biological activities. It has …
such as shrimp and crab, has been shown to have various biological activities. It has …
[HTML][HTML] Diagnostic and prognostic biomarkers for myocardial infarction
Y Wu, N Pan, Y An, M Xu, L Tan… - Frontiers in cardiovascular …, 2021 - frontiersin.org
The incidence of myocardial infarction (MI) increases every year worldwide. Better
diagnostic and prognostic biomarkers for clinical applications are the consistent pursuit of MI …
diagnostic and prognostic biomarkers for clinical applications are the consistent pursuit of MI …
Impacts of land use/land cover change on climate and future research priorities
In short, the above discussion clearly identified the importance of LULCC in the climate
system. It has also been established in the literature that biases, inaccuracies, and …
system. It has also been established in the literature that biases, inaccuracies, and …
Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in …
XQ Yu, GJ Robbie, Y Wu, MT Esser… - Antimicrobial agents …, 2017 - Am Soc Microbiol
ABSTRACT MEDI4893 is an investigational immunoglobulin G1 (κ) monoclonal antibody
that specifically binds to and neutralizes alpha-toxin, a key Staphylococcus aureus virulence …
that specifically binds to and neutralizes alpha-toxin, a key Staphylococcus aureus virulence …
Genetic biomarkers for hepatocellular carcinoma in the era of precision medicine
J Duan, Y Wu, J Liu, J Zhang, Z Fu, T Feng… - Journal of …, 2019 - Taylor & Francis
Being one of the most lethal cancers that exhibit high levels of heterogeneity, hepatocellular
carcinoma (HCC) is associated with diverse oncogenic pathways underpinned by varied …
carcinoma (HCC) is associated with diverse oncogenic pathways underpinned by varied …
[HTML][HTML] Phase 1 study of MEDI3902, an investigational anti–Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults
SO Ali, XQ Yu, GJ Robbie, Y Wu, K Shoemaker… - Clinical microbiology …, 2019 - Elsevier
Objectives MEDI3902 is a bivalent, bispecific human immunoglobulin G1κ monoclonal
antibody that binds to both the Pseudomonas aeruginosa PcrV protein involved in host cell …
antibody that binds to both the Pseudomonas aeruginosa PcrV protein involved in host cell …
Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind …
B François, HS Jafri, J Chastre… - The lancet infectious …, 2021 - thelancet.com
Background Staphylococcus aureus remains a common cause of ventilator-associated
pneumonia, with little change in incidence over the past 15 years. We aimed to evaluate the …
pneumonia, with little change in incidence over the past 15 years. We aimed to evaluate the …
Wnt/β‐catenin signaling pathway upregulates c‐Myc expression to promote cell proliferation of P19 teratocarcinoma cells
S Zhang, Y Li, Y Wu, K Shi, L Bing… - The Anatomical Record …, 2012 - Wiley Online Library
Aberrant activation of the Wnt/β‐catenin signaling pathway is a common event in human
tumor progression. Wnt signaling has also been implicated in maintaining a variety of adult …
tumor progression. Wnt signaling has also been implicated in maintaining a variety of adult …
[HTML][HTML] Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
Y Wu, C Lu, N Pan, M Zhang, Y An, M Xu, L Zhang… - Scientific Reports, 2021 - nature.com
Most human diseases are systems diseases, and systems biomarkers are better fitted for
diagnostic, prognostic, and treatment monitoring purposes. To search for systems biomarker …
diagnostic, prognostic, and treatment monitoring purposes. To search for systems biomarker …
[HTML][HTML] First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced …
J Bendell, P LoRusso, M Overman, AM Noonan… - Cancer Immunology …, 2023 - Springer
Background CD73 upregulation in tumors leads to local immunosuppression. This phase I,
first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ …
first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ …