Completion of base excision repair by mammalian DNA ligases
AE Tomkinson, L Chen, Z Dong, JB Leppard… - Progress in nucleic acid …, 2001 - Elsevier
Three mammalian genes encoding DNA ligases—LIG1, LIG3, and LIG4—have been
identified. Genetic, biochemical, and cell biology studies indicate that the products of each of …
identified. Genetic, biochemical, and cell biology studies indicate that the products of each of …
Physical and functional interaction between DNA ligase IIIα and poly (ADP-ribose) polymerase 1 in DNA single-strand break repair
JB Leppard, Z Dong, ZB Mackey… - Molecular and cellular …, 2003 - Taylor & Francis
The repair of DNA single-strand breaks in mammalian cells is mediated by poly (ADP-
ribose) polymerase 1 (PARP-1), DNA ligase IIIα, and XRCC1. Since these proteins are not …
ribose) polymerase 1 (PARP-1), DNA ligase IIIα, and XRCC1. Since these proteins are not …
[HTML][HTML] Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma
MA Postow, M Manuel, P Wong, J Yuan, Z Dong… - … for immunotherapy of …, 2015 - Springer
Background Ipilimumab improves overall survival in a subset of patients with metastatic
melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been associated …
melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been associated …
A pilot study of preoperative single-dose ipilimumab and/or cryoablation in women with early-stage breast cancer with comprehensive immune profiling
HL McArthur, A Diab, DB Page, J Yuan… - Clinical Cancer …, 2016 - AACR
Purpose: To assess the safety and tolerability of preoperative cryoablation-mediated tumor
antigen presentation and/or ipilimumab-mediated immune modulation in women with …
antigen presentation and/or ipilimumab-mediated immune modulation in women with …
[HTML][HTML] Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients
PB Subrahmanyam, Z Dong, D Gusenleitner… - … for immunotherapy of …, 2018 - Springer
Background While immune checkpoint blockade has greatly improved clinical outcomes in
diseases such as melanoma, there remains a need for predictive biomarkers to determine …
diseases such as melanoma, there remains a need for predictive biomarkers to determine …
Deep sequencing of T-cell receptor DNA as a biomarker of clonally expanded TILs in breast cancer after immunotherapy
In early-stage breast cancer, the degree of tumor-infiltrating lymphocytes (TIL) predicts
response to chemotherapy and overall survival. Combination immunotherapy with immune …
response to chemotherapy and overall survival. Combination immunotherapy with immune …
Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab
Ipilimumab, an antibody that blocks CTL antigen 4 (CTLA-4), improves overall survival (OS)
for patients with metastatic melanoma. Given its role in angiogenesis and immune evasion …
for patients with metastatic melanoma. Given its role in angiogenesis and immune evasion …
[HTML][HTML] The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage
The Nijmegen breakage syndrome (NBS), a chromosomal instability disorder, is
characterized in part by cellular hypersensitivity to ionizing radiation. Repair of DNA double …
characterized in part by cellular hypersensitivity to ionizing radiation. Repair of DNA double …
Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors
BACKGROUND Targeting programmed cell death protein 1 (PD‐1) and indoleamine 2, 3‐
dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS The …
dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS The …
[HTML][HTML] The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion
O Korkina, Z Dong, A Marullo, G Warshaw… - Journal of Biological …, 2013 - ASBMB
The small GTPase RhoC is overexpressed in many invasive tumors and is essential for
metastasis. Despite its high structural homology to RhoA, RhoC appears to perform …
metastasis. Despite its high structural homology to RhoA, RhoC appears to perform …