Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly
in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the …

Immunologic responses to anti-PD-1 therapy in melanoma patients occur rapidly with
pharmacodynamic T cell responses detectable in blood by 3 weeks. It is unclear, however, …

Positron emission tomography (PET) is a radiotracer imaging method that yields quantitative
images of regional in vivo biology and biochemistry. PET, now used in conjunction with …

Advances in the treatment of metastatic melanoma have improved responses and survival.
However, many patients continue to experience resistance or toxicity to treatment, …

Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only
a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T …

There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-infiltrating
CD8+ leukocytes. Such imaging probes could be used to predict early response …

Positron emission tomography (PET) is a minimally invasive imaging procedure with a wide
range of clinical and research applications. PET allows for the three-dimensional mapping of …

BACKGROUND. Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad
population of patients with ovarian cancer; however, resistance caused by low enzyme …

Cell-based therapeutics have considerable promise across diverse medical specialties;
however, reliable human imaging of the distribution and trafficking of genetically engineered …

Background We conducted a phase I trial evaluating pembrolizumab+hypofractionated
radiotherapy (HFRT) for patients with metastatic cancers. Methods There were two strata (12 …