Roles of the NF-κB Pathway in Lymphocyte Development and Function
- 1The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia
- 2Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
- Correspondence: gerondakis{at}burnet.edu.au, usiebenlist{at}niaid.nih.gov
Abstract
This article focuses on the functions of NF-κB that vitally impact lymphocytes and thus adaptive immunity. NF-κB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-κB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-κB executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-κB’s physiologic impact that we address in this article.
Footnotes
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Editors: Louis M. Staudt and Michael Karin
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Additional Perspectives on NF-κB available at www.cshperspectives.org
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