Genes Coding for Tumor-specific Rejection Antigens
This extract was created in the absence of an abstract.
Excerpt
Mouse tumors induced with chemical carcinogens or UV light are immunogenic: Tumor cells killed by irradiation or living tumor cells later removed by surgery confer to the inoculated animal a lasting protection against a challenge with the same tumor cells (Klein et al. 1960; Kripke and Fisher 1976). This specific protection was the first evidence for the existence of specific tumor rejection antigens. T lymphocytes were shown to carry the specific memory involved in these responses. Later, it became apparent that many tumors, including most, if not all, spontaneous tumors, do not elicit any immune rejection response (Hewitt et al. 1976). However, from such nonimmunogenic tumor cell lines that were treated in vitro with a mutagen, it was possible to derive variants that expressed potent new antigens (Van Pel et al. 1983). These “tum−” variants were rejected by syngeneic mice, and these mice were protected against a challenge with the...
