Section Edited by Douglas G. McNeel, MD, PhD; Claudia Palena, PhD; and Jeffrey S. Weber, MD, PhD
Clinical trials: prospective studies including first-in-man clinical trials, phase II/III clinical studies, and immune monitoring investigations. Small, single institution-based retrospective reports are discouraged.
Preclinical studies: studies that lead to mechanistic understanding or novel development of agents and combination therapies directly relevant to human immunotherapy.
Dendritic cell therapy augments antitumor immunity triggered by CDK4/6 inhibition and immune checkpoint blockade by unleashing systemic CD4 T-cell responsesAmrendra Kumar, Vijay Ramani, Vijaya Bharti, Daniel de Lima Bellan, Nabil Saleh, Roman Uzhachenko, Chengli Shen, Carlos Arteaga, Ann Richmond, Sangeetha M Reddy, Anna Vilgelm
25 May 2023
Long-term follow-up of anti-PD-1 naïve patients with metastatic melanoma treated with IDO/PD-L1 targeting peptide vaccine and nivolumabCathrine Lund Lorentzen, Julie Westerlin Kjeldsen, Eva Ehrnrooth, Mads Hald Andersen, Inge Marie Svane
22 May 2023
Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanomaFlorian Märkl, Mohamed-Reda Benmebarek, Julius Keyl, Bruno L Cadilha, Martina Geiger, Clara Karches, Hannah Obeck, Melanie Schwerdtfeger, Stefanos Michaelides, Daria Briukhovetska, Sophia Stock, Jakob Jobst, Philipp Jie Müller, Lina Majed, Matthias SeifertSee the full list of authors
19 May 2023
CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC modelsJian Ye, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Tara G Vrooman, Maggie L Lesch, Carl J Johnston, Edith M Lord, Brian A Belt, David C Linehan, Jim Eyles, Scott A Gerber
4 May 2023
Talimogene laherparepvec in combination with ipilimumab versus ipilimumab alone for advanced melanoma: 5-year final analysis of a multicenter, randomized, open-label, phase II trialJason A Chesney, Igor Puzanov, Frances A Collichio, Parminder Singh, Mohammed M Milhem, John Glaspy, Omid Hamid, Merrick Ross, Philip Friedlander, Claus Garbe, Theodore Logan, Axel Hauschild, Celeste Lebbé, Harshada Joshi, Wendy SnyderSee the full list of authors
4 May 2023
Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinomaNicholas H Chakiryan, Youngchul Kim, Anders Berglund, Andrew Chang, Gregory J Kimmel, Ali Hajiran, Jonathan Nguyen, Carlos Moran-Segura, Daryoush Saeed-Vafa, Esther N Katende, Neale Lopez-Blanco, Jad Chahoud, Phillip Rappold, Philippe E Spiess, Michelle FournierSee the full list of authors
25 April 2023
Tumor and immune remodeling following radiotherapy in human renal cell carcinomaJacky Chow, Adil Khan, Madeline Gaudieri, Brianna J Wasik, Alexis Conway, Kah Teong Soh, Elizabeth A Repasky, Thomas Schwaab, Paul K Wallace, Scott I Abrams, Anurag K Singh, Jason B Muhitch
20 April 2023
Irreversible electroporation augments β-glucan induced trained innate immunity for the treatment of pancreatic ductal adenocarcinomaMatthew R Woeste, Rejeena Shrestha, Anne E Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M McMasters, Robert C G MartinSee the full list of authors
18 April 2023
Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapySandhya Sharma, Mae Woods, Naren U Mehta, Tim Sauer, Kathan S Parikh, Michael Schmueck-Henneresse, Huimin Zhang, Birju Mehta, Malcolm K Brenner, Helen E Heslop, Cliona M Rooney
18 April 2023
Brain metastasis and survival outcomes after first-line therapy in metastatic melanoma: a multicenter DeCOG study on 1704 patients from the prospective skin cancer registry ADOREGCindy Franklin, Peter Mohr, Leonie Bluhm, Friedegund Meier, Marlene Garzarolli, Michael Weichenthal, Katharina Kähler, Imke Grimmelmann, Ralf Gutzmer, Jochen Utikal, Patrick Terheyden, Rudolf Herbst, Sebastian Haferkamp, Claudia Pfoehler, Andrea ForschnerSee the full list of authors
7 April 2023