Section Edited by Marcela V. Maus, MD, PhD
Immune cell therapies and cell engineering approaches, new targets, novel functionalities, clinical trial results, correlative studies in patients who have received cell-based therapies, novel engineering strategies (molecular switches, conditional expression, logic gating), gene-edited cells to knock out or knock in novel functions, synthetic gene circuits. Includes pre-clinical animal modeling (small and large) and clinical trials.
Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapyLydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Julia Taylor, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie CerecSee the full list of authors
30 June 2023
BiTE secretion by adoptively transferred stem-like T cells improves FRα+ ovarian cancer controlA J Robert McGray, Jessie L Chiello, Takemasa Tsuji, Mark Long, Kathryn Maraszek, Nicole Gaulin, Spencer R Rosario, Suzanne M Hess, Scott I Abrams, Danuta Kozbor, Kunle Odunsi, Emese Zsiros
23 June 2023
Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy studySophie Papa, Antonella Adami, Michael Metoudi, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Fiona Reid, Maria Elstad, Nicholas Beckley-Hoelscher, Abdel Douri, Marc Delord, Mike Lyne, Dharshene ShivapathamSee the full list of authors
15 June 2023
CD22 CAR T-cell associated hematologic toxicities, endothelial activation and relationship to neurotoxicityJennifer Jess, Bonnie Yates, Alina Dulau-Florea, Kevin Parker, Jon Inglefield, Dan Lichtenstein, Fiorella Schischlik, Martin Ongkeko, Yanyu Wang, Shilpa Shahani, Ann Cullinane, Hannah Smith, Eli Kane, Lauren Little, Dong ChenSee the full list of authors
9 June 2023
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse modelDiana Rose E Ranoa, Preeti Sharma, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother, Edward J RoySee the full list of authors
31 May 2023
Cell surface marker-based capture of neoantigen-reactive CD8 T-cell receptors from metastatic tumor digestsPraveen D Chatani, Frank J Lowery, Neilesh B Parikh, Kyle J Hitscherich, Rami Yossef, Victoria Hill, Jared J Gartner, Biman Paria, Maria Florentin, Satyajit Ray, Alakesh Bera, Maria Parkhust, Paul Robbins, Sri Krishna, Steven A Rosenberg
31 May 2023
Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemiaAnil Kumar, Adeleh Taghi Khani, Caroline Duault, Soraya Aramburo, Ashly Sanchez Ortiz, Sung June Lee, Anthony Chan, Tinisha McDonald, Min Huang, Norman J. Lacayo, Kathleen M. Sakamoto, Jianhua Yu, Christian Hurtz, Martin Carroll, Sarah K. TasianSee the full list of authors
22 May 2023
CAR T-cell detection scoping review: an essential biomarker in critical need of standardizationDavid P Turicek, Victoria M Giordani, Josquin Moraly, Naomi Taylor, Nirali N Shah
22 May 2023
Use of cytokine-induced killer cell therapy in patients with colorectal cancer: a systematic review and meta-analysisCeline Man Ying Li, Yoko Tomita, Bimala Dhakal, Runhao Li, Jun Li, Paul Drew, Timothy Price, Eric Smith, Guy J Maddern, Kevin Aaron Fenix
28 April 2023
Severe cytopenia after CD19 CAR T-cell therapy: a retrospective study from the EBMT Transplant Complications Working PartyOlaf Penack, Christophe Peczynski, Christian Koenecke, Emmanuelle Polge, Andrea Kuhnl, Nathalie Fegueux, Michael Daskalakis, Nicolaus Kröger, Peter Dreger, Caroline Besley, Urs Schanz, Adrian Bloor, Arnold Ganser, Edouard Forcade, Lucia López CorralSee the full list of authors
18 April 2023