Section Edited by Marcela V. Maus, MD, PhD
Immune cell therapies and cell engineering approaches, new targets, novel functionalities, clinical trial results, correlative studies in patients who have received cell-based therapies, novel engineering strategies (molecular switches, conditional expression, logic gating), gene-edited cells to knock out or knock in novel functions, synthetic gene circuits. Includes pre-clinical animal modeling (small and large) and clinical trials.
Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6Young Eun Lee, Ga-Yeon Go, Eun-Young Koh, Han-Na Yoon, Minkoo Seo, Seung-Mo Hong, Ji Hye Jeong, Jin-Chul Kim, Duck Cho, Tae Sung Kim, Song Cheol Kim, Eunsung Jun, Mihue Jang
27 February 2023
Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapyNatalia Plewa, Lucia Poncette, Thomas Blankenstein
23 February 2023
TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastomaMaximilian O Schaettler, Rupen Desai, Anthony Z Wang, Alexandra J Livingstone, Dale K Kobayashi, Andrew T Coxon, Jay A Bowman-Kirigin, Connor J Liu, Mao Li, Diane E Bender, Michael J White, David M Kranz, Tanner M Johanns, Gavin P Dunn
20 February 2023
IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBMMarkella Zannikou, Joseph T Duffy, Rebecca N Levine, Maggie Seblani, Qianli Liu, Aaron Presser, Victor A Arrieta, Christopher J Chen, Adam M Sonabend, Craig M Horbinski, Catalina Lee-Chang, Jason Miska, Maciej S Lesniak, Stephen Gottschalk, Irina V Balyasnikova
9 February 2023
Immunotherapy reverses glioma-driven dysfunction of immune system homeostasisBayli DiVita Dean, Tyler Wildes, Joseph Dean, Oleg Yegorov, Changlin Yang, David Shin, Connor Francis, John W Figg, Mathew Sebastian, Laura Falceto Font, Dan Jin, Alexandra Reid, Ginger Moore, Brandon Fernandez, Brandon WummerSee the full list of authors
7 February 2023
Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer modelsEsther Schoutrop, Thomas Poiret, Ibrahim El-Serafi, Ying Zhao, Rui He, Alina Moter, Johan Henriksson, Moustapha Hassan, Isabelle Magalhaes, Jonas Mattsson
6 February 2023
TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cellsJiacheng Bi, Chen Huang, Xiaomeng Jin, Chaoyue Zheng, Yingying Huang, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
1 February 2023
Antitumor effect of CAR-T cells targeting transmembrane tumor necrosis factor alpha combined with PD-1 mAb on breast cancersHongping Ba, Zigang Dai, Zunyue Zhang, Peng Zhang, Bingjiao Yin, Jing Wang, Zhuoya Li, Xiaoxi Zhou
31 January 2023
Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stromaMary K McKenna, Ada Ozcan, Daniel Brenner, Norihiro Watanabe, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, Challice Bonifant, David M Markovitz, Malcolm K Brenner
18 January 2023
Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastomaMing Sun, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Haiying Qin, Nan Li, Charlie Seibert, Michael C Kelly, Eytan Ruppin, Mitchell Ho, Carol J Thiele, Rosa Nguyen
11 January 2023