Immunotherapy Biomarkers

Section Edited by Ignacio Melero, MD, PhD and Alexandra Snyder Charen, MD

Consisting of predictive/prognostic biomarker studies, gene expression studies in cancer immunotherapy, serological immune biomarkers, multiparameter flow cytometry-defined immune biomarkers, high content immunohistological studies, clinical trial analyses and identification of novel immune biomarkers. Manuscripts will be prioritized for peer review and publication on the basis of innovation/novelty of the biomarker-oriented research, adequate validation, clinical relevance and technological novelty.

Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade

Michal Harel, Coren Lahav, Eyal Jacob, Nili Dahan, Itamar Sela, Yehonatan Elon, Shani Raveh Shoval, Galit Yahalom, Iris Kamer, Alona Zer, Ofer Sharon, David P Carbone, Adam P Dicker, Jair Bar, Yuval Shaked

10.1136/jitc-2022-004582

June 19, 2022

Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer

Sakti Chakrabarti, Leslie Bucheit, Jason Scott Starr, Racquel Innis-Shelton, Ardaman Shergill, Hiba Dada, Regina Resta, Stephanie Wagner, Naomi Fei, Pashtoon Murtaza Kasi

10.1136/jitc-2021-004485

June 16, 2022

Association of race/ethnicity with innate immune tumor microenvironment of children with B-acute lymphoblastic leukemia

Julie R Gilbert, Himalee S Sabnis, Roman Radzievski, Deon B Doxie, Deborah DeRyckere, Sharon M Castellino, Kavita Dhodapkar

10.1136/jitc-2022-004774

June 16, 2022

Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab

Geoffrey Alan Watson, Enrique Sanz-Garcia, Wen-Jiang Zhang, Zhihui Amy Liu, SY Cindy Yang, Ben Wang, Shaofeng Liu, Shawn Kubli, Hal Berman, Thomas Pfister, Sofia Genta, Anna Spreafico, Aaron R Hansen, Philippe L Bedard, Stephanie Lheureux, Albiruni Abdul Razak, Dave Cescon, Marcus O Butler, Wei Xu, Tak W Mak, Lillian L Siu, Eric Chen

10.1136/jitc-2021-004378

June 15, 2022

Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer

Zhenghang Wang, Qi Zhang, Changsong Qi, Yuezong Bai, Feilong Zhao, Hui Chen, Zhongwu Li, Xicheng Wang, Mifen Chen, Jifang Gong, Zhi Peng, Xiaotian Zhang, Jinping Cai, Shiqing Chen, Xiaochen Zhao, Lin Shen, Jian Li

10.1136/jitc-2022-004703

June 15, 2022

Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy

Michael Hwang, Jenna Vanliere Canzoniero, Samuel Rosner, Guangfan Zhang, James R White, Zineb Belcaid, Christopher Cherry, Archana Balan, Gavin Pereira, Alexandria Curry, Noushin Niknafs, Jiajia Zhang, Kellie N Smith, Lavanya Sivapalan, Jamie E Chaft, Joshua E Reuss, Kristen Marrone, Joseph C Murray, Qing Kay Li, Vincent Lam, Benjamin P Levy, Christine Hann, Victor E Velculescu, Julie R Brahmer, Patrick M Forde, Tanguy Seiwert, Valsamo Anagnostou

10.1136/jitc-2022-004688

June 10, 2022

Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy

Grace Heloise Attrill, Carina N Owen, Tasnia Ahmed, Ismael A Vergara, Andrew J Colebatch, Jordan W Conway, Kazi J Nahar, John F Thompson, Ines Pires da Silva, Matteo S Carlino, Alexander M Menzies, Serigne Lo, Umaimainthan Palendira, Richard A Scolyer, Georgina V Long, James S Wilmott

10.1136/jitc-2022-004771

June 10, 2022

T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma

Xuefeng Wang, Jameel Muzaffar, Kedar Kirtane, Feifei Song, Matthew Johnson, Michael J Schell, Jiannong Li, Sean J Yoder, Jose R Conejo-Garcia, Jose A Guevara-Patino, Marcelo Bonomi, Priyanka Bhateja, James W Rocco, Conor E Steuer, Nabil F Saba, Christine H Chung

10.1136/jitc-2022-004512

June 8, 2022

Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer

Miguel Lopez de Rodas, Venkata Nagineni, Arvind Ravi, Ila J Datar, Mari Mino-Kenudson, German Corredor, Cristian Barrera, Lindsey Behlman, David L Rimm, Roy S Herbst, Anant Madabhushi, Jonathan W Riess, Vamsidhar Velcheti, Matthew D Hellmann, Justin Gainor, Kurt A Schalper

10.1136/jitc-2021-004440

June 1, 2022

Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients

Sara Bruschini, Matteo Pallocca, Eleonora Sperandio, Lorenzo D’Ambrosio, Francesca Ascenzi, Claudia De Vitis, Valentina Salvati, Antonella Esposito, Simona Di Martino, Francesca De Nicola, Francesca Paolini, Luigi Fattore, Gabriele Alessandrini, Francesco Facciolo, Maria Laura Foddai, Massimiliano Bassi, Federico Venuta, Michela D’Ascanio, Alberto Ricci, Antonio D’ Andrilli, Christian Napoli, Luigi Aurisicchio, Maurizio Fanciulli, Erino Angelo Rendina, Gennaro Ciliberto, Rita Mancini

10.1136/jitc-2021-004239

May 18, 2022