Immunotherapy Biomarkers

Section Edited by Ignacio Melero, MD, PhD and Alexandra Snyder Charen, MD

Consisting of predictive/prognostic biomarker studies, gene expression studies in cancer immunotherapy, serological immune biomarkers, multiparameter flow cytometry-defined immune biomarkers, high content immunohistological studies, clinical trial analyses and identification of novel immune biomarkers. Manuscripts will be prioritized for peer review and publication on the basis of innovation/novelty of the biomarker-oriented research, adequate validation, clinical relevance and technological novelty.

Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab

Geoffrey Alan Watson, Enrique Sanz-Garcia, Wen-Jiang Zhang, Zhihui Amy Liu, SY Cindy Yang, Ben Wang, Shaofeng Liu, Shawn Kubli, Hal Berman, Thomas Pfister, Sofia Genta, Anna Spreafico, Aaron R Hansen, Philippe L Bedard, Stephanie Lheureux, Albiruni Abdul Razak, Dave Cescon, Marcus O Butler, Wei Xu, Tak W Mak, Lillian L Siu, Eric Chen

10.1136/jitc-2021-004378

June 15, 2022

Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy

Michael Hwang, Jenna Vanliere Canzoniero, Samuel Rosner, Guangfan Zhang, James R White, Zineb Belcaid, Christopher Cherry, Archana Balan, Gavin Pereira, Alexandria Curry, Noushin Niknafs, Jiajia Zhang, Kellie N Smith, Lavanya Sivapalan, Jamie E Chaft, Joshua E Reuss, Kristen Marrone, Joseph C Murray, Qing Kay Li, Vincent Lam, Benjamin P Levy, Christine Hann, Victor E Velculescu, Julie R Brahmer, Patrick M Forde, Tanguy Seiwert, Valsamo Anagnostou

10.1136/jitc-2022-004688

June 10, 2022

Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients

Sara Bruschini, Matteo Pallocca, Eleonora Sperandio, Lorenzo D’Ambrosio, Francesca Ascenzi, Claudia De Vitis, Valentina Salvati, Antonella Esposito, Simona Di Martino, Francesca De Nicola, Francesca Paolini, Luigi Fattore, Gabriele Alessandrini, Francesco Facciolo, Maria Laura Foddai, Massimiliano Bassi, Federico Venuta, Michela D’Ascanio, Alberto Ricci, Antonio D’ Andrilli, Christian Napoli, Luigi Aurisicchio, Maurizio Fanciulli, Erino Angelo Rendina, Gennaro Ciliberto, Rita Mancini

10.1136/jitc-2021-004239

May 18, 2022