Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy

Michael Hwang; Jenna Vanliere Canzoniero; Samuel Rosner; Guangfan Zhang; James R White; Zineb Belcaid; Christopher Cherry; Archana Balan; Gavin Pereira; Alexandria Curry; Noushin Niknafs; Jiajia Zhang; Kellie N Smith; Lavanya Sivapalan; Jamie E Chaft; Joshua E Reuss; Kristen Marrone; Joseph C Murray; Qing Kay Li; Vincent Lam; Benjamin P Levy; Christine Hann; Victor E Velculescu; Julie R Brahmer; Patrick M Forde; Tanguy Seiwert; Valsamo Anagnostou

doi:10.1136/jitc-2022-004688

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Immunotherapy biomarkers

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Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy

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Michael Hwang The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Jenna Vanliere Canzoniero The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Samuel Rosner The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Guangfan Zhang The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
James R White The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Zineb Belcaid The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Christopher Cherry The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Archana Balan The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Gavin Pereira The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Alexandria Curry The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Noushin Niknafs The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Jiajia Zhang The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Kellie N Smith The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Lavanya Sivapalan The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Jamie E Chaft Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articles Google scholar articles
Joshua E Reuss Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA PubMed articles Google scholar articles
Kristen Marrone The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Joseph C Murray The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Qing Kay Li The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Vincent Lam The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Benjamin P Levy The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Christine Hann The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Victor E Velculescu The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Julie R Brahmer The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Patrick M Forde The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Tanguy Seiwert The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Valsamo Anagnostou The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles

Correspondence to Dr Valsamo Anagnostou; vanagno1{at}jhmi.edu

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Citation

Hwang M, Canzoniero JV, Rosner S, et al

Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy

Journal for ImmunoTherapy of Cancer 2022;10:e004688. doi: 10.1136/jitc-2022-004688

Publication history

Accepted May 9, 2022
First published June 10, 2022.

Online issue publication

January 24, 2024

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This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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