Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers

Chunhong Hu; Lishu Zhao; Wenliang Liu; Songqing Fan; Junqi Liu; Yuxuan Liu; Xiaohan Liu; Long Shu; Xianling Liu; Ping Liu; Chao Deng; Zhenhua Qiu; Chen Chen; Yi Jiang; Qingchun Liang; Lingling Yang; Yang Shao; Qiongzhi He; Danlei Yu; Yue Zeng; Yizheng Li; Yue Pan; Sujuan Zhang; Shenghao Shi; Yurong Peng; Fang Wu

doi:10.1136/jitc-2021-003773

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Basic tumor immunology

Original research

Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers

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Chunhong Hu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, ChinaHunan Cancer Mega-Data Intelligent Application and Engineering Research Centre, Changsha, China PubMed articles Google scholar articles
Lishu Zhao Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Wenliang Liu Department of Thoracic Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Songqing Fan Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Junqi Liu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Yuxuan Liu Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China PubMed articles Google scholar articles
Xiaohan Liu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Long Shu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Xianling Liu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Ping Liu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Chao Deng Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Zhenhua Qiu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Chen Chen Department of Thoracic Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Yi Jiang Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Qingchun Liang Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Lingling Yang Geneseeq Research Institute, Nanjing Geneseeq Technology Inc, Nanjing 210032, China PubMed articles Google scholar articles
Yang Shao Geneseeq Research Institute, Nanjing Geneseeq Technology Inc, Nanjing 210032, China PubMed articles Google scholar articles
Qiongzhi He Geneplus-Beijing Institute, Beijing, China PubMed articles Google scholar articles
Danlei Yu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Yue Zeng Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Yizheng Li Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Yue Pan Department of Oncology, Central South University, Changsha, China PubMed articles Google scholar articles
Sujuan Zhang Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Shenghao Shi Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Yurong Peng Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China PubMed articles Google scholar articles
Fang Wu Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, ChinaHunan Cancer Mega-Data Intelligent Application and Engineering Research Centre, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, ChinaHunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China PubMed articles Google scholar articles

Correspondence to Dr Fang Wu; wufang4461{at}csu.edu.cn

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Citation

Hu C, Zhao L, Liu W, et al

Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers

Journal for ImmunoTherapy of Cancer 2021;9:e003773. doi: 10.1136/jitc-2021-003773

Publication history

Accepted November 16, 2021
First published December 9, 2021.

Online issue publication

October 25, 2022

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This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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