Section Edited by Howard L. Kaufman, MD, FACS
This section focuses on the role of therapeutic agents designed for targeting tumor cells and/or the tumor microenvironment. This includes oncolytic viruses, microbial agents, innate immune agonists, direct and systemically delivered proteins and DNA/RNA products that act within established tumors. Research describing the characterization and basic biology of oncolytic agents and novel delivery systems are encouraged. An emphasis on how novel intra-tumoral directed agents modulate local and systemic host innate and adaptive anti-tumor immunity are of particular interest. In addition, the section welcomes translational and clinical investigation involving new oncolytic immunotherapy agents or those that include an oncolytic approach as part of combination therapeutic regimens.
Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hostsMargaret Veitch, Kimberly Beaumont, Rebecca Pouwer, Hui Yi Chew, Ian H Frazer, H Peter Soyer, Scott Campbell, Brian W Dymock, Andrew Harvey, Terrie-Anne Cock, James W Wells
7 September 2023
ONCOS-102 plus pemetrexed and platinum chemotherapy in malignant pleural mesothelioma: a randomized phase 2 study investigating clinical outcomes and the tumor microenvironmentSantiago Ponce, Susana Cedrés, Charles Ricordel, Nicolas Isambert, Santiago Viteri, Mercedes Herrera-Juarez, Alex Martinez-Marti, Alejandro Navarro, Mathieu Lederlin, Xavier Serres, Jon Zugazagoitia, Sylvia Vetrhus, Magnus Jaderberg, Thomas Birkballe Hansen, Victor LevitskySee the full list of authors
3 September 2023
Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancerRenato Brito Baleeiro, Peng Liu, Louisa S Chard Dunmall, Carmela Di Gioia, Ai Nagano, Lauren Cutmore, Jun Wang, Claude Chelala, Lydon Wainaina Nyambura, Peter Walden, Nicholas Lemoine, Yaohe Wang
16 August 2023
Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablationMohammad Alshebremi, Suzanne L Tomchuck, Jay T Myers, Daniel T Kingsley, Saada Eid, Muta Abiff, Melissa Bonner, Shahrazad T Saab, Sung Hee Choi, Alex Yee-Chen Huang
8 August 2023
Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-primingMark Aleynick, Judit Svensson-Arvelund, Gvantsa Pantsulaia, Kristy Kim, Samuel A Rose, Ranjan Upadhyay, Michael Yellin, Henry Marsh, Daniel Oreper, Suchit Jhunjhunwala, Christine Carine Moussion, Miriam Merad, Brian D Brown, Joshua D Brody
24 July 2023
Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancerSachin R Jhawar, Shang-Jui Wang, Aditya Thandoni, Praveen K Bommareddy, Jenna H Newman, Eileena F Giurini, Amanda L Marzo, Timothy M Kuzel, Vineet Gupta, Jochen Reiser, Preston Daniels, Devora Schiff, Darrion Mitchell, Nicole R LeBoeuf, Christopher SimmonsSee the full list of authors
11 July 2023
Intralesional administration of VAX014 facilitates in situ immunization and potentiates immune checkpoint blockade in immunologically cold tumorsKatherine A Reil, Shingo Tsuji, Elsa Molina, Kinsey L Nelson, Kathleen L McGuire, Matthew J Giacalone
8 June 2023
Defects in intratumoral arginine metabolism attenuate the replication and therapeutic efficacy of oncolytic myxoma virusParker Dryja, Heather D Curtsinger, Mee Y Bartee, Eric Bartee
2 June 2023
Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lungArthur Battistoni, Louis Lantier, Anne di Tommaso, Céline Ducournau, Laurie Lajoie, Mahtab Samimi, Loïs Coënon, Clément Rivière, Mathieu Epardaud, Leslie Hertereau, Agathe Poupée-Beaugé, Juliette Rieu, Marie-Noëlle Mévélec, Gordon Scott Lee, Nathalie MoiréSee the full list of authors
16 May 2023
Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosisDuo Wang, Guanhua Qiu, Xiaoqi Zhu, Qin Wang, Chunyan Zhu, Chao Fang, Junjie Liu, Kun Zhang, Yan Liu
16 May 2023