Immunotherapy Biomarkers

Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade
Michal Harel, Coren Lahav, Eyal Jacob, Nili Dahan, Itamar Sela, Yehonatan Elon, Shani Raveh Shoval, Galit Yahalom, Iris Kamer, Alona Zer, Ofer Sharon, David P Carbone, Adam P Dicker, Jair Bar, Yuval Shaked

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004582; DOI: 10.1136/jitc-2022-004582
Association of race/ethnicity with innate immune tumor microenvironment of children with B-acute lymphoblastic leukemia
Julie R Gilbert, Himalee S Sabnis, Roman Radzievski, Deon B Doxie, Deborah DeRyckere, Sharon M Castellino, Kavita Dhodapkar

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004774; DOI: 10.1136/jitc-2022-004774
Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer
Sakti Chakrabarti, Leslie Bucheit, Jason Scott Starr, Racquel Innis-Shelton, Ardaman Shergill, Hiba Dada, Regina Resta, Stephanie Wagner, Naomi Fei, Pashtoon Murtaza Kasi

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004485; DOI: 10.1136/jitc-2021-004485
Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer
Zhenghang Wang, Qi Zhang, Changsong Qi, Yuezong Bai, Feilong Zhao, Hui Chen, Zhongwu Li, Xicheng Wang, Mifen Chen, Jifang Gong, Zhi Peng, Xiaotian Zhang, Jinping Cai, Shiqing Chen, Xiaochen Zhao, Lin Shen, Jian Li

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004703; DOI: 10.1136/jitc-2022-004703
Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab
Geoffrey Alan Watson, Enrique Sanz-Garcia, Wen-Jiang Zhang, Zhihui Amy Liu, SY Cindy Yang, Ben Wang, Shaofeng Liu, Shawn Kubli, Hal Berman, Thomas Pfister, Sofia Genta, Anna Spreafico, Aaron R Hansen, Philippe L Bedard, Stephanie Lheureux, Albiruni Abdul Razak, Dave Cescon, Marcus O Butler, Wei Xu, Tak W Mak, Lillian L Siu, Eric Chen

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004378; DOI: 10.1136/jitc-2021-004378
Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy
Grace Heloise Attrill, Carina N Owen, Tasnia Ahmed, Ismael A Vergara, Andrew J Colebatch, Jordan W Conway, Kazi J Nahar, John F Thompson, Ines Pires da Silva, Matteo S Carlino, Alexander M Menzies, Serigne Lo, Umaimainthan Palendira, Richard A Scolyer, Georgina V Long, James S Wilmott

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004771; DOI: 10.1136/jitc-2022-004771
Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy
Michael Hwang, Jenna Vanliere Canzoniero, Samuel Rosner, Guangfan Zhang, James R White, Zineb Belcaid, Christopher Cherry, Archana Balan, Gavin Pereira, Alexandria Curry, Noushin Niknafs, Jiajia Zhang, Kellie N Smith, Lavanya Sivapalan, Jamie E Chaft, Joshua E Reuss, Kristen Marrone, Joseph C Murray, Qing Kay Li, Vincent Lam, Benjamin P Levy, Christine Hann, Victor E Velculescu, Julie R Brahmer, Patrick M Forde, Tanguy Seiwert, Valsamo Anagnostou

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004688; DOI: 10.1136/jitc-2022-004688
T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma
Xuefeng Wang, Jameel Muzaffar, Kedar Kirtane, Feifei Song, Matthew Johnson, Michael J Schell, Jiannong Li, Sean J Yoder, Jose R Conejo-Garcia, Jose A Guevara-Patino, Marcelo Bonomi, Priyanka Bhateja, James W Rocco, Conor E Steuer, Nabil F Saba, Christine H Chung

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004512; DOI: 10.1136/jitc-2022-004512
Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer
Miguel Lopez de Rodas, Venkata Nagineni, Arvind Ravi, Ila J Datar, Mari Mino-Kenudson, German Corredor, Cristian Barrera, Lindsey Behlman, David L Rimm, Roy S Herbst, Anant Madabhushi, Jonathan W Riess, Vamsidhar Velcheti, Matthew D Hellmann, Justin Gainor, Kurt A Schalper

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004440; DOI: 10.1136/jitc-2021-004440
Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients
Sara Bruschini, Matteo Pallocca, Eleonora Sperandio, Lorenzo D’Ambrosio, Francesca Ascenzi, Claudia De Vitis, Valentina Salvati, Antonella Esposito, Simona Di Martino, Francesca De Nicola, Francesca Paolini, Luigi Fattore, Gabriele Alessandrini, Francesco Facciolo, Maria Laura Foddai, Massimiliano Bassi, Federico Venuta, Michela D’Ascanio, Alberto Ricci, Antonio D’ Andrilli, Christian Napoli, Luigi Aurisicchio, Maurizio Fanciulli, Erino Angelo Rendina, Gennaro Ciliberto, Rita Mancini

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004239; DOI: 10.1136/jitc-2021-004239

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