Immunotherapy Biomarkers

Machine learning-based integration develops a metabolism-derived consensus model for improving immunotherapy in pancreatic cancer
Yongdong Guo, Ronglin Wang, Jingjie Shi, Cheng Yang, Peixiang Ma, Jie Min, Ting Zhao, Lei Hua, Yang Song, Junqiang Li, Haichuan Su

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007466; DOI: 10.1136/jitc-2023-007466
Assessing treatment outcomes of chemoimmunotherapy in extensive-stage small cell lung cancer: an integrated clinical and radiomics approach
Jie Zhao, Yayi He, Xue Yang, Panwen Tian, Liang Zeng, Kun Huang, Jing Zhao, Jiaqi Zhou, Yin Zhu, Qiyuan Wang, Mailin Chen, Wen Li, Yi Gao, Yongchang Zhang, Yang Xia

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007492; DOI: 10.1136/jitc-2023-007492
Siglec-9⁺ tumor-associated macrophages delineate an immunosuppressive subset with therapeutic vulnerability in patients with high-grade serous ovarian cancer
Yiying Wang, Mengdi He, Chen Zhang, Kankan Cao, Guodong Zhang, Moran Yang, Yan Huang, Wei Jiang, Haiou Liu

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007099; DOI: 10.1136/jitc-2023-007099
Synergic prognostic value of 3D CT scan subcutaneous fat and muscle masses for immunotherapy-treated cancer
Pierre Decazes, Samy Ammari, Younes Belkouchi, Léo Mottay, Littisha Lawrance, Antoine de Prévia, Hugues Talbot, Siham Farhane, Paul-Henry Cournède, Aurelien Marabelle, Florian Guisier, David Planchard, Tony Ibrahim, Caroline Robert, Fabrice Barlesi, Pierre Vera, Nathalie Lassau

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007315; DOI: 10.1136/jitc-2023-007315
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Aleksandar Obradovic, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Catherine Spina, Charles G Drake, Matthew C Dallos, Benjamin Izar

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006782; DOI: 10.1136/jitc-2023-006782
Location of CD39⁺ T cell subpopulations within tumors predict differential outcomes in non-small cell lung cancer
Lilian Koppensteiner, Layla Mathieson, Samuel Pattle, David A Dorward, Richard O’Connor, Ahsan R Akram

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006770; DOI: 10.1136/jitc-2023-006770
hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC
Paola Trono, Annalisa Tocci, Belinda Palermo, Anna Di Carlo, Lorenzo D'Ambrosio, Daniel D'Andrea, Francesca Di Modugno, Francesca De Nicola, Frauke Goeman, Giacomo Corleone, Sarah Warren, Francesca Paolini, Mariangela Panetta, Isabella Sperduti, Silvia Baldari, Paolo Visca, Silvia Carpano, Federico Cappuzzo, Vincenzo Russo, Claudio Tripodo, Paolo Zucali, Vanesa Gregorc, Federica Marchesi, Paola Nistico

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006913; DOI: 10.1136/jitc-2023-006913
T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy
Bettzy Stephen, Joud Hajjar, Shrutii Sarda, Dzifa Yawa Duose, Jeffrey M Conroy, Carl Morrison, Anas Alshawa, Mingxuan Xu, Abdulrazzak Zarifa, Sapna P Patel, Ying Yuan, Evan Kwiatkowski, Linghua Wang, Jordi Rodon Ahnert, Siqing Fu, Funda Meric-Bernstam, Geoffrey M Lowman, Timothy Looney, Aung Naing

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007236; DOI: 10.1136/jitc-2023-007236
Intratumoral T-cell and B-cell receptor architecture associates with distinct immune tumor microenvironment features and clinical outcomes of anti-PD-1/L1 immunotherapy
Aimilia Schina, Zsofia Sztupinszki, Inge Marie Svane, Zoltan Szallasi, Göran Jönsson, Marco Donia

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006941; DOI: 10.1136/jitc-2023-006941
Depicting the landscape of gut microbial-metabolic interaction and microbial-host immune heterogeneity in deficient and proficient DNA mismatch repair colorectal cancers
Jinming Li, Yangyang Guo, Jianqiang Liu, Fanying Guo, Lutao Du, Yongzhi Yang, Xinxiang Li, Yanlei Ma

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007420; DOI: 10.1136/jitc-2023-007420

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