Immunotherapy Biomarkers

Immunologic constant of rejection signature is prognostic in soft-tissue sarcoma and refines the CINSARC signature
Francois Bertucci, Vincent Niziers, Alexandre de Nonneville, Pascal Finetti, Léna Mescam, Olivier Mir, Antoine Italiano, Axel Le Cesne, Jean-Yves Blay, Michele Ceccarelli, Davide Bedognetti, Daniel Birnbaum, Emilie Mamessier

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003687; DOI: 10.1136/jitc-2021-003687
Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy
Jonas Bochem, Henning Zelba, Janine Spreuer, Teresa Amaral, Andrea Gaissler, Oltin T Pop, Karolin Thiel, Can Yurttas, Daniel Soffel, Stephan Forchhammer, Tobias Sinnberg, Heike Niessner, Friedegund Meier, Patrick Terheyden, Alfred Königsrainer, Claus Garbe, Lukas Flatz, Graham Pawelec, Thomas K Eigentler, Markus W Löffler, Benjamin Weide, Kilian Wistuba-Hamprecht

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003439; DOI: 10.1136/jitc-2021-003439
Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival
Manish A Shah, David Cunningham, Jean-Philippe Metges, Eric Van Cutsem, Zev Wainberg, Emon Elboudwarej, Kai-Wen Lin, Scott Turner, Marianna Zavodovskaya, David Inzunza, Jinfeng Liu, Scott D Patterson, Jingzhu Zhou, Jing He, Dung Thai, Pankaj Bhargava, Carrie Baker Brachmann, Daniel V T Cantenacci

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003580; DOI: 10.1136/jitc-2021-003580
Gut microbiome is associated with the clinical response to anti-PD-1 based immunotherapy in hepatobiliary cancers
Jinzhu Mao, Dongxu Wang, Junyu Long, Xu Yang, Jianzhen Lin, Yiwei Song, Fucun Xie, Ziyu Xun, Yanyu Wang, Yunchao Wang, Yiran Li, Huishan Sun, Jingnan Xue, Yang Song, Bangyou Zuo, Junwei Zhang, Jin Bian, Ting Zhang, Xiaobo Yang, Lei Zhang, Xinting Sang, Haitao Zhao

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003334; DOI: 10.1136/jitc-2021-003334
Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-small cell lung cancer
Joao V Alessi, Biagio Ricciuti, Stephanie L Alden, Arrien A Bertram, Jessica J Lin, Mustafa Sakhi, Mizuki Nishino, Victor R Vaz, James Lindsay, Madison M Turner, Kathleen Pfaff, Bijaya Sharma, Kristen D Felt, Scott J. Rodig, Justin F. Gainor, Mark M. Awad

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003536; DOI: 10.1136/jitc-2021-003536
Pan-cancer landscape of CD274 (PD-L1) rearrangements in 283,050 patient samples, its correlation with PD-L1 protein expression, and immunotherapy response
Andrew D Kelly, Karthikeyan Murugesan, Zheng Kuang, Meagan Montesion, Jeffrey S Ross, Lee A Albacker, Richard S P Huang, Douglas I Lin, Umut Demirci, James Creeden

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003550; DOI: 10.1136/jitc-2021-003550
Genomic alterations in biliary tract cancer predict prognosis and immunotherapy outcomes
Xiaofeng Chen, Deqiang Wang, Jing Liu, Jingrong Qiu, Jun Zhou, Jieer Ying, Yan Shi, Zhaoxia Wang, Haizhou Lou, Jiuwei Cui, Jingdong Zhang, Yunpeng Liu, Fengjiao Zhao, Lanlan Pan, Jianyi Zhao, Dongqin Zhu, Shiqing Chen, Xiangcheng Li, Xue Li, Liuqing Zhu, Yang Shao, Yongqian Shu

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003214; DOI: 10.1136/jitc-2021-003214
A Machine learning model trained on dual-energy CT radiomics significantly improves immunotherapy response prediction for patients with stage IV melanoma
Andreas Stefan Brendlin, Felix Peisen, Haidara Almansour, Saif Afat, Thomas Eigentler, Teresa Amaral, Sebastian Faby, Adria Font Calvarons, Konstantin Nikolaou, Ahmed E Othman

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003261; DOI: 10.1136/jitc-2021-003261
TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment
Shusuke Kawashima, Takashi Inozume, Masahito Kawazu, Toshihide Ueno, Joji Nagasaki, Etsuko Tanji, Akiko Honobe, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Tomonori Kawasaki, Yukiko Kiniwa, Osamu Yamasaki, Satoshi Fukushima, Yuzuru Ikehara, Hiroyuki Mano, Yutaka Suzuki, Hiroyoshi Nishikawa, Hiroyuki Matsue, Yosuke Togashi

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003134; DOI: 10.1136/jitc-2021-003134
Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer
Jenny Sprooten, Ann Vankerckhoven, Isaure Vanmeerbeek, Daniel M Borras, Yani Berckmans, Roxanne Wouters, Raquel S Laureano, Thais Baert, Louis Boon, Chiara Landolfo, Antonia Carla Testa, Daniela Fischerova, Caroline Van Holsbeke, Tom Bourne, Valentina Chiappa, Wouter Froyman, Dominique Schols, Patrizia Agostinis, Dirk Timmerman, Sabine Tejpar, Ignace Vergote, An Coosemans, Abhishek D Garg

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003609; DOI: 10.1136/jitc-2021-003609

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