Immunotherapy Biomarkers

Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial
Carlos Jiménez-Cortegana, Natalia Palazón-Carrión, Alejandro Martin Garcia-Sancho, Esteban Nogales-Fernandez, Fernando Carnicero-González, Eduardo Ríos-Herranz, Fatima de la Cruz-Vicente, Guillermo Rodríguez-García, Rubén Fernández-Álvarez, Antonio Rueda Dominguez, Maria Casanova-Espinosa, Natividad Martínez-Banaclocha, Josep Gumà-Padrò, José Gómez-Codina, Jorge Labrador, Antonio Salar-Silvestre, Delvys Rodriguez-Abreu, Laura Galvez-Carvajal, Mariano Provencio, Margarita Sánchez-Beato, María Guirado-Risueño, Pablo Espejo-García, Marylene Lejeune, Tomás Álvaro, Victor Sánchez-Margalet, Luis de la Cruz-Merino

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002323; DOI: 10.1136/jitc-2020-002323
Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy
Lin Xie, Kuan Hu, Yanhong Duo, Takashi Shimokawa, Katsushi Kumata, Yiding Zhang, Cuiping Jiang, Lulu Zhang, Nobuki Nengaki, Hidekatsu Wakizaka, Yihai Cao, Ming-Rong Zhang

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002616; DOI: 10.1136/jitc-2021-002616
Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models
Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Stacy Kentner, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Hormas Ghadially, Matthew J Robinson, Tim Slidel, Robert W Wilkinson, Simon J Dovedi

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002894; DOI: 10.1136/jitc-2021-002894
Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer
Libin Zhang, Yanhui Chen, Han Wang, Zheyuan Xu, Yang Wang, Sixing Li, Jun Liu, Yun Chen, Hongli Luo, Lijia Wu, Ying Yang, Henghui Zhang, Hao Peng

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002356; DOI: 10.1136/jitc-2021-002356
Non-invasive measurement of PD-L1 status and prediction of immunotherapy response using deep learning of PET/CT images
Wei Mu, Lei Jiang, Yu Shi, Ilke Tunali, Jhanelle E Gray, Evangelia Katsoulakis, Jie Tian, Robert J Gillies, Matthew B Schabath

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002118; DOI: 10.1136/jitc-2020-002118
Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression
Richard S.P. Huang, Brennan Decker, Karthikeyan Murugesan, Matthew Hiemenz, Douglas A. Mata, Gerald Li, James Creeden, Shakti H. Ramkissoon, Jeffrey S. Ross

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002558; DOI: 10.1136/jitc-2021-002558
Immune landscape and subtypes in primary resectable oral squamous cell carcinoma: prognostic significance and predictive of therapeutic response
Pengfei Diao, Yue Jiang, Yuanyuan Li, Xiang Wu, Jin Li, Chen Zhou, Lei Jiang, Wei Zhang, Enshi Yan, Ping Zhang, Xu Ding, Heming Wu, Hua Yuan, Jinhai Ye, Xiaomeng Song, Linzhong Wan, Yunong Wu, Hongbing Jiang, Yanling Wang, Jie Cheng

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002434; DOI: 10.1136/jitc-2021-002434
On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy
Pablo Nenclares, Lucinda Gunn, Heba Soliman, Mateo Bover, Amy Trinh, Isla Leslie, Kee Howe Wong, Alan Melcher, Kate Newbold, Chris M Nutting, Derfel ap Dafydd, Shreerang A Bhide, Kevin Harrington

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002718; DOI: 10.1136/jitc-2021-002718
A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery
Jeroen H A Creemers, W Joost Lesterhuis, Niven Mehra, Winald R Gerritsen, Carl G Figdor, I Jolanda M de Vries, Johannes Textor

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002032; DOI: 10.1136/jitc-2020-002032
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes
John A Ligon, Woonyoung Choi, Gady Cojocaru, Wei Fu, Emily Han-Chung Hsiue, Teniola F Oke, Nicholas Siegel, Megan H Fong, Brian Ladle, Christine A Pratilas, Carol D Morris, Adam Levin, Daniel S Rhee, Christian F Meyer, Ada J Tam, Richard Blosser, Elizabeth D Thompson, Aditya Suru, David McConkey, Franck Housseau, Robert Anders, Drew M Pardoll, Nicolas Llosa

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e001772; DOI: 10.1136/jitc-2020-001772

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