Immune Tolerance

T-cell tolerant fraction as a predictor of immune-related adverse events
Jared Ostmeyer, Jason Y Park, Mitchell S von Itzstein, David Hsiehchen, Farjana Fattah, Mary Gwin, Rodrigo Catalan, Shaheen Khan, Prithvi Raj, Edward K Wakeland, Yang Xie, David E Gerber

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e006437; DOI: 10.1136/jitc-2022-006437
Reactivation of low avidity tumor-specific CD8⁺ T cells associates with immunotherapeutic efficacy of anti-PD-1
Gessa Sugiyarto, Doreen Lau, Samuel Luke Hill, David Arcia-Anaya, Denise S M Boulanger, Eileen E Parkes, Edward James, Tim Elliott

Journal for ImmunoTherapy of Cancer Aug 2023, 11 (8) e007114; DOI: 10.1136/jitc-2023-007114
CD71⁺ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors
Najmeh Bozorgmehr, Isobel Okoye, Siavash Mashhouri, Julia Lu, Petya Koleva, John Walker, Shokrollah Elahi

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006595; DOI: 10.1136/jitc-2022-006595
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christine Sers, Christiane A Opitz, Benoit J Van den Eynde, Jingjing Zhu

Journal for ImmunoTherapy of Cancer Jun 2023, 11 (6) e006728; DOI: 10.1136/jitc-2023-006728
GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang, Kefeng Dou, Ran Zhuang, Boquan Jin, Wei Zhang, Qiang Hao, Kuo Zhang, Wangqian Zhang, Shuning Wang, Yuan Gao, Jintao Gu, Lei Shang, Zhijun Tan, Haichuan Su, Yingqi Zhang, Cun Zhang, Meng Li

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002787; DOI: 10.1136/jitc-2021-002787
Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy
Ryan C. Augustin, Robert D. Leone, Aung Naing, Lawrence Fong, Riyue Bao, Jason J. Luke

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e004089; DOI: 10.1136/jitc-2021-004089
Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite
Giorgia Renga, Emilia Nunzi, Marilena Pariano, Matteo Puccetti, Marina Maria Bellet, Giuseppe Pieraccini, Fiorella D’Onofrio, Ilaria Santarelli, Claudia Stincardini, Franco Aversa, Francesca Riuzzi, Cinzia Antognelli, Marco Gargaro, Oxana Bereshchenko, Maurizio Ricci, Stefano Giovagnoli, Luigina Romani, Claudio Costantini

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003725; DOI: 10.1136/jitc-2021-003725
Immuno-oncology trends: preclinical models, biomarkers, and clinical development
Maryland Rosenfeld Franklin, Suso Platero, Kamal S Saini, Giuseppe Curigliano, Steven Anderson

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003231; DOI: 10.1136/jitc-2021-003231
Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment
Feiya Ma, Jensen Vayalil, Grace Lee, Yuqi Wang, Guangyong Peng

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (10) e003217; DOI: 10.1136/jitc-2021-003217
Pan-cancer landscape of CD274 (PD-L1) rearrangements in 283,050 patient samples, its correlation with PD-L1 protein expression, and immunotherapy response
Andrew D Kelly, Karthikeyan Murugesan, Zheng Kuang, Meagan Montesion, Jeffrey S Ross, Lee A Albacker, Richard S P Huang, Douglas I Lin, Umut Demirci, James Creeden

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003550; DOI: 10.1136/jitc-2021-003550

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